✅Anti-TB Drugs

Question 1

Aside from neurotoxicity, what are the notable side effects of isomiazid?

Answer 1

Drug induced lupus

Acute hemolysis in G6PD

Question 2

Most important drug in tuberculosis

Answer 2

Isoniazid

Question 3

Specific vitamin B that treats neuropathy of isoniazid

Answer 3

Pyridoxine (B6)

Question 4

MOA of rifampicin

Answer 4

Inhibits DNA dependent RNA polymerase

Question 5

Other notable side effects of Rifampicin aside from red orange urine

Answer 5

Flu like Sx

Hepatotoxicity

Question 6

MOA of ethambutol

Answer 6

Inhibits arabinosyl transferases involved in the synthesis of arabinogalactan in mycobacterial cell wall

Question 7

What type of colorblindness is ethambutol predisposed to?

Answer 7

Red green color blindness

Question 8

MOA of pyrazinamide

Answer 8

Unknown

Question 9

Other than hepatotoxicity, what is the other notable SE of pyrazinamide?

Answer 9

Hyperuricemia

Question 10

Hepatotoxic anti TB drugs

Answer 10

ISO a RED PYRE

Isoniazid

Question 11

Treatment regimen for category II TB (WHO)

Answer 11

Cat 2 - sputum smear pos, relapse, treatment failure, defaulter

2HRZES, 1HRZE, 5HR

Question 12

Most active drug against M leprae

Answer 12

Dapsone

Question 13

MOA of dapsone

Answer 13

Inhibition of folic acid synthesis

Question 14

Notable side effect of dapsone

Answer 14

GI upset
Methemoglobinemia
Acute hemolysis in G6PD

Question 15

Used in dapsone resistant leprosy

Answer 15

Clofazimine

Question 16

MOA of clofazimine

Answer 16

Binds to guanine bases in bacterial DNA

Question 17

Notable SE of clofazimine

Answer 17

GI irritation

Skin discoloration

Question 18

Drugs for atypical mycobacteria

Answer 18

Prophylaxis:
Azithromycin or clarithromycin With or without Rifabutin

Tx:
Azith or clarith with ethambutol and rifabutin

Question 19

MOA of isoniazid

Answer 19

Inhibits mycolic acid synthesis