✅Antibiotic - Bacterial Cell Wall Synthesis Inhibitors Flashcards Preview

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Flashcards in ✅Antibiotic - Bacterial Cell Wall Synthesis Inhibitors Deck (58):
1

Bactericidal antibiotics

Mnemonic: Very Finely proficient at murder

Vancomycin
Fluoroquinolone
Penicillin
Aminoglycoside
Metronidazole

2

Bacteriostatic antibiotics

We're ECSTaTiC about bacteriostatics!

Erythromycin
Clindamycin
Sulfamethoxazole
Trimetophrim
Tetracycline
Chloramphenicol

3

MOA of beta lactam antibiotics

binds to penicillin binding proteins (PBP) in the bacterial cytoplasmic membrane

Inhibits the transpeptidation reaction that cross-links the linear peptidolycan chains constituents

4

Staph aureus exhibits this property against beta lactam antibiotics

Enzymatic hydrolysis of beta lactam ring by beta lactamases

5

Example of beta lactamase inhibitors

Clavulanic acid, sulbactam, tazobactam

6

Penicillin resistance exhibited by MRSA, pneumococci, enterococci

structural changes in PBPs

7

What bacteria exhibits penicillin resistance by changing the porin structures in the outer cell wall impeding access of penicillins to PBP

Pseudomonas aeruginosa

8

Very narrow spectrum penicillin

Methicillin

nafcillin, oxacillin, cloxacillin

9

Antipseudomonal penicillins.

What other infections does this drug treat aside from pseudomonas?

"Takes Care of Pseudomonas"

Ticarcillin, Carbenicillin, Piperacillin

Enterobacter, Klebsiella

10

Renal tubular reabsorption of penicillin G is inhibited by

Probenecid

11

Which Penicillin is oral? IV?

Pen G or Pen V

Pen V -oral (vunganga)

Pen G - IV (inGect)

12

Methicillin is a very narrow spectrum penicillin used mainly for

Staphylococcus infections

13

Side effect of Nafcillin

neutropenia

14

Which very narrow spectrum penicillin causes Interstitial Nephritis?

Methicillin

15

Common side effect of penicillins

Hypersensitivity, GI upset

16

Ampicillin is known to cause which notable side effect?

Pseudomembranous colitis and rash

17

Which penicillin has greater oral bioavailability

Amoxicillin

18

Describe the antimicrobial coverage of extended spectrum antibiotics?

Amoxicillin HELPS kill Enterococci

Haemophilus influenzae
E. coli
Listeria monocytogenes
P. mirabilis
Salmonella spp.
Enterococci

19

Piperacillin and ampicillin have enhanced effects with ______ and synergistic effects with _______

beta lactamase inhibitors
aminoglycosides

20

Coverage of 1st gen cephalosporins

PEKs first

Proteus
E. coli
Klebsiella

21

Which cephalosporins are synergistic with aminoglycosides and which increases nephrotoxicity when combined with them?

Increases nephrotoxicity - 1st gen and 2nd gen
Synergistic - 3rd gen

22

Which generation of cephalosporin?

Cefadroxil

1st

23

Which generation of cephalosporin?

Cephalothin

1st

24

Which generation of cephalosporin?

Cephapirin

1st

25

Which generation of cephalosporin?

Cephradine

1st

26

Which generation of cephalosporin?

Cephalexin

1st

27

Which generation of cephalosporin?

Cefomandole

2nd

28

Which generation of cephalosporin?

Cefonicid

2nd

29

Which generation of cephalosporin?

Cefprozil

2nd

30

Loracarbef is a ?

2nd gen cephalosporin

31

Which generation of cephalosporin?

Ceforanide

2nd

32

Which generation of cephalosporin?

Cefoxitin

2nd

33

Which generation of cephalosporin?

Cefmetazole

2nd

34

Which generation of cephalosporin?

Cefotetan

2nd

35

Which generation of cephalosporin?

2nd

36

Cefotetan and Cefomandole are unique 2nd gen cephalosporins because they exhibit ____

disulfiram reaction

37

Which microbes are covered by 2nd gen cephalosporins?

HEN PEKS

Haemophilus influenzae
Enterobacter aeorgenes
Neiserria spp.

Proteus
E. coli
Klebsiella
Serratia

38

Which generation of cephalosporin?

Cefotaxime

3rd

39

Which generation of cephalosporin?

Ceftazidime

3rd

40

Which generation of cephalosporin?

Ceftizoxime

3rd

41

Which generation of cephalosporin?

Cefixime

3rd

42

Which generation of cephalosporin?

Cefpodoxime proxetil

3rd

43

Which generation of cephalosporin?

Cefdinir

3rd

44

Which generation of cephalosporin?

Cefditoren pivoxil

3rd

45

Which generation of cephalosporin?

Ceftibuten

3rd

46

Which generation of cephalosporin?

Moxalactam

3rd

47

3rd gen cephalosporin that exhibits disulfiram reaction

cefoperazone

48

Which cephalosporins are antipseudomonal?

Ceftazidime
Cefepime
Cefoperazone

49

____ inhibits renal metabolism of Imipinem

Cilastatin

50

Monobactam mainly used for gram negative rods (Klebsiella, Pseudomonas, Serratia)

Aztreonam

51

Aztreonam has no effect on

gram positive or anaerobes

52

MOA of Vancomycin

Inhibits cell wall synthesis by binding to the D-ala-D-ala terminus of nascent peptidoglycan

53

How is Red Man syndrome treated?

Slow the rate of vancomycin infusion?

54

Antibiotic Drugs of last resort

I AM your Last Shot at Victory

Imipenem
Amikacin
Meropenem
Linezolid
Streptogramin
Vancomycin

55

Main side effect of bacitracin

Nephrotoxicity (that is why only used topically)

56

MOA of bacitracin

Interferes with late stage in cell wall synthesis in Gram + organisms

57

MOA of cycloserine and name another drug with the same MOA

Blocks incorporation of D-Ala into the pentapeptide side chain of the peptidoglycan

Vancomycin

58

Bacitracina and cycloserine are 2nd line treatments for

XDR-TB