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Flashcards in GI Drugs Deck (23):
1

MOA of Antacids

Neutralize stomach acid by reacting with protons in the lumen of the gut

2

Magnesium hydroxide causes _____ while Aluminum hydroxide causes _______

Magnesium = MAGtatae = Diarrhea
Aluminum = Ayaw LUMabas = Constipation

3

Cimetidine has modest effect on meal-stimulated secretion but highly effective in _____ acid secretion

Nocturnal

4

Name 3 mucosal protective agents

Sucralfate, Misoprostol, Bismuth

5

Quadruple therapy in H. pylori infection

Omeprazole, Bismuth, Metronidazole, Tetracycline

6

SE of Bismuth

Black stools, darkening of tongue, Encephalopathy

7

Prokinetic antimicrobial
What is the MOA?

Erythromycin
Activates motilin receptors

8

MOA of Metoclopramide and Domperidone

blocks D2 receptors

9

Drug of Choice for Diabetic Gastroparesis

Metoclopramide

10

Why is domperidone preferred over metoclopramide?

Domperidone does not cross the BBB

11

Triple therapy in H. pylori infection

Omeprazole. Ranitidine, Amox or Metronid

12

MOA of Psyllium

Indigestible bulky colloids that absorb water forming a bulky emollient gel that distends colon and promotes peristalsis

13

MOA of Docusate

stool-softening

14

MOA of lactulose

osmotic laxative

15

MOA of bisacodyl

Directly stimulate enteric nervous system

16

Usual laxative given as preparation for endoscopy

Polyethylene glycol

17

SE of Bisacodyl (benign condition)

Melanosis coli

18

Example of antidiarrheals

Loperamide
Diphenoxylate

19

MOA of antidiarrheals and SE

Activates opioid receptors in the enteric nervous system

Paralytic Ileus

20

Paralytic ileus is reversed by

Betanechol

21

Used in vomiting (post op and post chemo)
Give MOA

Ondansetron

5HT3 receptor antagonist

22

Which 5HT3 antagonist can cause QRS and QT prolongation

Dolasetron

23

Drug used in IBD

Mesalamine

Balsalazide
Olsalazine
Sulfasalazine