✅Antifungals

Question 1

MOAs of antifungal agents

Answer 1

Alter cell membrane permeability
Blocks nucleic acid synthesis
Disrupt microtubule function

Question 2

Systemic Drugs for Superficial Mycoses

Answer 2

Griseofulvin

Terbinafine

Question 3

Topical Drugs for Superficial Fungal Infections

Answer 3

Nystatin

Clotrimazole

Question 4

MOA of polyenes

Answer 4

Binds to ergosterol in fungal membranes forming artificial pores.

Question 5

MOA of terbinafine

Answer 5

interfere with ergosterol synthesis by inhibiting squalene oxidase

Question 6

MOA of azoles

Answer 6

inhibit fungal P450 enzyme blocking ergosterol synthesis

Question 7

MOA of flucytosine

Answer 7

Accumulated in fungal cells by permease and converted by CYTOSINE DEAMINASE to 5-FU, which inhibits thymidilate synthase

Question 8

Filipinos are exquisitely susceptible to which fungal infection

Answer 8

Coccidiomycosis

Question 9

Drug class of caspofungin

Answer 9

echinocandins

Question 10

MOA of echinocandins

Answer 10

Inhibits beta-glucan synthesis and polymerization of nucleic acids

Question 11

notable side effect of ketoconazole

Answer 11

gynecomastia

Question 12

Flushing (histamine release) is a side effect of what antifungal?

Answer 12

Caspofungin

Question 13

MOA of griseofulvin

Answer 13

inhibits microtubule function

Question 14

antifungal that accumulates keratin

Answer 14

terbinafine

Question 15

antifungal that is contraindicated in porphyria

Answer 15

griseofulvin

Question 16

Nystatin aside from topical prep is also available in what preparation?

Answer 16

Swish and swallow prep

Question 17

Antifungal that exhibits disulfiram reaction

Answer 17

Griseofulvin

Question 18

main SE of nystatin

Answer 18

Nephrotoxicity

Question 19

Griseofulvin is a potent CYP ____?

Answer 19

inducer

Question 20

Ketoconazole is a CYP _____?

Answer 20

inhibitor