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Flashcards in ✅Antivirals Deck (47):
1

MOA of docosanol (anti herpes)

Inihibits the fusion between HSV envelope and plasma membranes

2

HSV without this enzyme are resistant to acyclovir

Thymidine kinase

3

Ganciclovir is used mainly for

CMV infections

Can be used for HSV, VZV

4

MOA of ganciclovir

Inhibits viral DNA polymerase

5

2 drugs used for CMV retinitis and resistance with acyclovir or cmv

Cidofovir and foscarnet

6

Main SE of cidofovid and foscarnet

Nephrotoxicity

7

What drugs are used for thymidine kinase absent HSV?

Cidofovir or foscarnet

8

MOA of cidofovir

Inhibits viral DNA polymerase. Causing chain termination

9

MOA Of foscarnet

Inhibits viral rna polymerase, dna polymerase and HIV reverse transcriptase.

Binds to the pyroFOSphate binding site.

10

HAART stands for

Highly active antiretroviral therapy

11

HAART entails the use of how many drugs?

3 or more drugs
If possible before sx appear

12

Usual composition of HAART

2 NRTIs and 1 protease inhibitor

13

Receptors on cells for HIV attachment and specific drug that inhibits this step

CCR5

Maraviroc

14

Fusion inhibitor drug for HIV

EnFUvirtide

15

MOA of Enfuvirtide

Binds to the gp41 subunit of the viral envelope glycoprotein inhibiting fusion of viral and cellular membranes

16

All proetase inhibitors of HIV ends in

-navir

Ex. Indinavir, lopinavir

17

SE of HIV protease inhibitors (INDINAVIR)

Hyperlipidemia
Fat redistribution

18

Which protease inhibitor has a side effect of peripheral neuropathy?

Atazanavir

19

Which protease inhibitor has a side effect of rash?

Amprenavir

20

Aside from hyperlipdemia, what is another notable side effect of indinavir?

Hyperbilirubinemia and nephrolithiasis

21

Only integrase inhibitor of HIV

Raltegravir

22

NNRTIs

Never Ever Deliver Nucleosides

Nevirapine
Efavirenz
Etravirine
Delavirdine

23

SE of delavirdine and nevirapine

Rash, increased LFTs

24

Known teratogenic among the NNRTIs

Efavirenz

25

NNRTi that is both a cyp inducer and inhibitor

Etravirine

26

MOA of NNRTIs vs NRTIs

Both inhibit reverse transcriptase

NNRTI - no phosphorylation required

NRTI- inhibits after phosphorylation

27

Main SE of NRTIs

Lactic acidosis with hepatic steatosis

28

What NRTI causes bone marrow suppression

Zidovudine

29

What NRTI is known to cause hypersensitivity

Abacavir

30

Known NRTI to cause pancreatitis

Didanosine

31

NRTIs that cause peripheral neuropathy

Stavudine, zalcitabine

32

MOA of amantidine

Inhibits early replication and uncoating by binding to M2 proton channels

33

Use of amantadine

Influenza A only

34

Use of oseltamivir

Influenza A and B

35

Notable side effects of amantadine

GI irritation, dizziness, cerebellar dysfxn (ataxia and dysarthria)
LIVEDO RETICULARIS

36

Amantadine is used in treating what neurolgic disease

Parkinsons

37

MOA of oseltamivir/zanamavir

Inhibits NEURAMINIDASE decreasing release of progeny virus

38

SE of oseltamivir

GI effects

39

SE of zanamavir

Bronchospasm in asthmatics

40

Which anti hep B drug is also used in HIV?

Lamivudine (NRTI)

41

Coinfection of Hep B and HIV might cause _____ with Lamivudine use

Pancreatitis

42

MOA of acyclovir

Activated by viral thymidine kinase to forms that inhibit viral DNA polymerase

43

MOA of interferon

Degrades viral RNA via activation of host cell RNAse (ribonuclease)

44

Contraindications of interferon use

Autoimmune disease, pregnancy, arrythmias

45

MOA of ribavarin

Inhibits guanosine triphosphate formation. Prevents capping of viral mRNA. Blocks RNA dependent RNA polymerases.

46

Early IV administration of ribavirin decreases mortality in _______

Viral hemorrhagic fevers

47

Uses of ribavirin

HCV, RSV