Antibiotics Flashcards
(34 cards)
Beta-Lactams
Inhibits cell wall CROSSLINKING (synthesis): Penicillins, Cephalosporins, Monobactams, Carbapenems
DOES THIS BY IRREVERSIBLY BINDING TRANSPEPIDASES (Penicillin Binding Proteins) PREVENTING CROSSLINKING
Restance occurs via beta-lactamases (degrades lactams) and by mutating Penicllin binding proteins so drugs no longer have affinity to PCPs
Vanco (glycopeptide) actually binds the D-ALA D-ALA parts of the cell.
Penicillin, Methicillin, Oxacillin
When do you use Naficillin?
D-ala-D-ala peptidoglycan side chain, inhibiting transpeptidase from forming crosslinks
Resistance develops vai lactamase expression. Counter with lactamase inhibitor
“Use Naf for staph” aures (not MRSA tho)
Ampicillin kills?
“HELPSS” kill enterococci
H Flu, E coli, Listeria monocytogenes, Proteus, Salmonella, Shigella
Piperacillin
Combo with Tazobactam (b-lactamase)
Used specifically for Psuedomonas A.
Efficacy against G+, G-, and Anaerobes (psuedo is an aerobe than can also be a faculative anaerobe–grows very well in low/no O2)
Clavulanic Acid
Beta Lactmase Inhibitor. Given with Beta lactams to increase their half lives as well to be used in bacteria expressing beta-lactamases.
Monobactams
Beta-lactams that only have one ring. Less likely to act as haptens thus they are good to use in G- infections in ppl w/ Pencillin allergies.
Aztreonam
Cephalosporins
Cef’s cover?
Cef’s don’t cover?
Beta Lactams: Prefix: Cefs;
Increased resistance to beta-lactamases
Cover (2nd gen): HEN PEcKS (H flu, Enterobacter, Neisseria, Proteus, E coli, Kleb, Serratia)
Don’t Cover: “LAME” Listeria, Atypicals (chlamy, Mycoplasma), MRSA, Enterococci
Worsen Nephrotoxicity of Aminoglycocides
4th Generation best for Psuedomonas (Cefepime)
Carbapenems (Imipenem)
Beta-lactam, Big Gun used in ICUs
ALWAYS ADMINISTERED WITH Cilastatin**** (decreases renal tubular inactivation by inhibiting renal dehydropeptidase I)
Binds PBP’s like cillins.
Last Resort used for highly resistant organisms (klebseilla, serratia (red ring on toilet), enterobacter) because of GI/Seizure SEs
Vancomycin
Glycopeptides, G+: Inhibits elongation via D-ala D-ala binding.
Enterococci have resistance by switching to D-ala-D-lactose, which can be horizontally transfered to Staph Aur via VRE plasmid
“Glyco_P_eptide works like _P_enicillin”
Bacitracin
Glycopeptide, G+, inhibits NAG-NAM tranpsort to outer wall
Protein Synthesis Inhbitors
- Aminoglycosides–Targets 30s portion of Ribosome
- Tetracycline/Doxycycline–
- Chloramphenicol
- Macrolides
- Lincosamides
- Mupriocin
Aminoglycosides
Strepomycin, Gentamycin, Tobramycin, Amikacin, Neomycin (GANTS)
Anti-30s subunit of Ribo; post-antibiotic effect (activity persists beyond detectable amounts)
“Aminoglycosides=small protein sugars used to inhibit the smaller part of the ribo”
ACUTE RENAL FAILURE** (made worse by Cephalosporins)
“GANTS caNNOT kill anaerobes”
N-ephrotox, N-euromuscular blockade, O-totox, T-eratogen
Tetracycline/Doxycycline
Competes with tRNA for A site on 30s (“with tetracyclines the ribosome never has a chance to start cycling”–prevents initiation)
Active against G+/- and protozoa
Not for children dt deposition in teeth (grey) or bone (deformation)
“Vacum the bedroom” Vibrio, Acne, chlamydia, Ureaplasma, Mycoplasma, Tuleramia, H Pylori, Borrellia, Rickettsia”
Chloramphenicol
Binds 50s inhibiting translocation of ribosome
Protein synth inhibitor
Macrolides
Erythromycin, Azithromycin (Z-pak)
Binds 50s subunit inhibiting translocation “macrolides stop the ribo slide”
Risk of Prolonged QT**** (“z prolongs the qt”)
Erythro: also has GI/Liver (p450) issues
“MACRO”: Motility (GI) issues, Arrthymias (Qt), Cholestatic hepatitis, Rash, eOsinophillia
“Atypical PUS: Atyipical Pneumonia (myco and legionella), URI, STDs”
Clindamycin
Protien synth inhibitor; binds to 23s portion of the 50s ribo subunit, causing premature tRNA dissociation
Lincosamide class: Used for skin and soft tissue infections: SE–>pseudomembranous colitis
“Clinda causes premature ejac” of the ribosome
ANAEROBIC INFECTIONS (aspiration pneumonia, lung abscesses, MRSA)
CAUSES C. DIFF INFECTION
Mupirocin
Protein Synth Inhibitor
Blocking protein synth via Inhibits isoleucyl tRNA synthase
Used for S. Aureus skin infections
Purine Synthesis Inhibitors
- DHF reductase inhibitors
- Suflonamides
Trimethoprim
DHF Reductase Inhibitors (methotrexate also hits DHFR)
Synergizes: TMP-SMZ
“TMP” Treats Marrow Poorly (megaloblastic anemia, leukopenia, granulocytopenia)
Sulfonamides
Analog of PABA blocking PABA–>Dihydropteroate synthase inhibitors (bacteria need to make folate since they cannot absorb it)
Synergizes: TMP-SMZ (Bactrim)
Hypersensitivity reactions, Hemolysis (G6PD def), nephrotox, photosensitivity, Kernicertus (thus dont use in Preggers), Stevens Johnson Syndrome
Flouoroquinolones
-floxacins (cipro, gemi, levo)
inhbitis DNA topoisomerase II (DNA GYRASE) “cipro-circular-gyrase”
UTIs from pseudomonas; prophylaxis for anthrax
Associated with ruptured tendons (damages cartilage), tendonitis (particularly achilles tendon) “Fluoroquinolones hurt attachments to your bones”
Metronidazole
Nitro group is released by bacterial metabolism and reacts with DNA
Flagyl, used for anaerobic bacteria nd protozoa
GET GAP on the Metro: Giardia, Entamoeba, Trichomona, Gardnerella, Anaerobic bacteria, h Pylori
DISULFIRAM LIKE REACTION W/ ETOH
Inhibitors of Cyp P450’s
“PICK EGS”
Protease Inhibitors, Isoniazid, Cimetidine/Cipro, Ketonacozle, Erythromycin, Grape Fruit Juice, Sulfonamides
Acute ETOH is inhibitor (Chronic is inducer)
Inducers of Cyp P450’s
BCG PQRS
Barbiturates, Carbamazepine, Grisesofluvin, Phenytoin, Quinidine, Rifampin, St. Johns Wort
Chronic ETOH=Inudcer (acute is inhibitor)
