Flashcards in Antibodies To Things Deck (48)
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1
Ds-DNA (double stranded DNA)
MOST highly specific for SLE
Lupus nephritis
2
What Ab can you order with a high sensitivity for SLE?
Ds-DNA
*a/w high specificity for SLE
*predicts lupus nephritis
*correlates with disease severity
3
What antibody do you order which is a/w lupus nephritis in SLE?
Double-stranded DNA or Anti-Sm
*also anti-Smith does as well
*ds-DNA has a high specificity for SLE, predicts disease severity, correlates with early/severe disease
4
Anti-Sm
A/w lupus nephritis, highly specific for SLE
*So is anti-dsDNA
5
Anti-rRNP (U1 RNP)
R-RNP - Highly specific for neuropsychiatric LE *per Jain
U1 RNP - Highly specific for MCTD *per Hocker
6
What antibody do you test if you are suspicious for neuropsychiatric LE?
Anti-rRNP (U1RNP)
7
Anti-Ro (SSA)
Anti-La (SSB)
SJOGRENS!(Most strong association)
SCLE
Neonatal lupus/congenital heart block
8
What antibodies do you order to check for SCLE
Anti Ro(SSA)/La(SSB)
*also a/w congenital heart block
9
Anti-SSA,Anti-SSB is the same Ab as what?
Anti-Ro/Anti-La
*checks for SCLE/neonatal lupus/congenital heart block/ AND Sjogrens
10
Antibody to check for neonatal lupus?
Anti-Ro/La (same thing as SSA/SSB)
11
Strongest Ab a.w Sjogrens
Anti-Ro, Anti-La
*MOST SPECIFIC -Anti fodrin
*which are also a/w SCLE/neonatal lupus
12
What two diseases is anti-Ro/La a/w?
SJOGRENS (strong) (sidenote* anti-fodrin is most specific)
SCLE/neonatal lupus
13
Anti-U1RNP
MCTD
*also can see in SCLE but mostly MCTD
14
Anti-histone
Drug induced SLE
15
Antibody indicating drug induced SLE/SCLE
Anti-his tone
16
Anti-KU
SLE with polymyositis
17
Antibody for drug induced polymyositis
Anti-KU
18
Anti-ssDNA
Increased risk of SLE in DLE
19
What antibody would you order in a DLE patient to assess their possible risk for SLE?
Anti-ssDNA
20
Anti-dsDNA
Anti-ssDNA
Anti-dsDNA is most specific test for SLE
Anti-ssDNA is risk of SLE within a DLE patient
21
Anti-C1q
Severe SLE
*URTICARIAL VASCULITIS
22
Test for antiphospholipid syndrome in SLE
Anti-cardiolipin
23
Anti-Fodrin
Most SPECIFIC for Sjogrens!!!
*also strong is anti-Ro/La
24
Which Ab a/w systemic disease and lymphoma in Sjogrens
Anti Ro (other Ab associated w Sjogrens are Ro/La and Fodrin)
25
Anti-Scl-70
Same thing as DNA-topoisomerase I (seen in systemic sclerosis)
26
Anti-Scl-70 is the same this as what antigen
DNA topoisomerase I. (Seen in severe systemic sclerosis)
27
Ab most strongly a/w diffuse skin disease in systemic sclerosis
Anti-Scl-70 (DNA topoisomerase I)
28
Anti-centromere
CREST
29
Ab a/w CREST
Anti-centromere
30
