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Flashcards in Antibodies To Things Deck (48)
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1

Ds-DNA (double stranded DNA)

MOST highly specific for SLE
Lupus nephritis

2

What Ab can you order with a high sensitivity for SLE?

Ds-DNA

*a/w high specificity for SLE
*predicts lupus nephritis
*correlates with disease severity

3

What antibody do you order which is a/w lupus nephritis in SLE?

Double-stranded DNA or Anti-Sm

*also anti-Smith does as well

*ds-DNA has a high specificity for SLE, predicts disease severity, correlates with early/severe disease

4

Anti-Sm

A/w lupus nephritis, highly specific for SLE

*So is anti-dsDNA

5

Anti-rRNP (U1 RNP)

R-RNP - Highly specific for neuropsychiatric LE *per Jain
U1 RNP - Highly specific for MCTD *per Hocker

6

What antibody do you test if you are suspicious for neuropsychiatric LE?

Anti-rRNP (U1RNP)

7

Anti-Ro (SSA)
Anti-La (SSB)

SJOGRENS!(Most strong association)
SCLE
Neonatal lupus/congenital heart block

8

What antibodies do you order to check for SCLE

Anti Ro(SSA)/La(SSB)
*also a/w congenital heart block

9

Anti-SSA,Anti-SSB is the same Ab as what?

Anti-Ro/Anti-La

*checks for SCLE/neonatal lupus/congenital heart block/ AND Sjogrens

10

Antibody to check for neonatal lupus?

Anti-Ro/La (same thing as SSA/SSB)

11

Strongest Ab a.w Sjogrens

Anti-Ro, Anti-La

*MOST SPECIFIC -Anti fodrin


*which are also a/w SCLE/neonatal lupus

12

What two diseases is anti-Ro/La a/w?

SJOGRENS (strong) (sidenote* anti-fodrin is most specific)
SCLE/neonatal lupus

13

Anti-U1RNP

MCTD
*also can see in SCLE but mostly MCTD

14

Anti-histone

Drug induced SLE

15

Antibody indicating drug induced SLE/SCLE

Anti-his tone

16

Anti-KU

SLE with polymyositis

17

Antibody for drug induced polymyositis

Anti-KU

18

Anti-ssDNA

Increased risk of SLE in DLE

19

What antibody would you order in a DLE patient to assess their possible risk for SLE?

Anti-ssDNA

20

Anti-dsDNA
Anti-ssDNA

Anti-dsDNA is most specific test for SLE
Anti-ssDNA is risk of SLE within a DLE patient

21

Anti-C1q

Severe SLE
*URTICARIAL VASCULITIS

22

Test for antiphospholipid syndrome in SLE

Anti-cardiolipin

23

Anti-Fodrin

Most SPECIFIC for Sjogrens!!!

*also strong is anti-Ro/La

24

Which Ab a/w systemic disease and lymphoma in Sjogrens

Anti Ro (other Ab associated w Sjogrens are Ro/La and Fodrin)

25

Anti-Scl-70

Same thing as DNA-topoisomerase I (seen in systemic sclerosis)

26

Anti-Scl-70 is the same this as what antigen

DNA topoisomerase I. (Seen in severe systemic sclerosis)

27

Ab most strongly a/w diffuse skin disease in systemic sclerosis

Anti-Scl-70 (DNA topoisomerase I)

28

Anti-centromere

CREST

29

Ab a/w CREST

Anti-centromere

30

Anti-RNA Polymerase III

Severe skin and KIDney disease in systemic sclerosis

*RNA polymerase the third, is part of a long family line with lots of KIDS, severe punishment for bad kids