Flashcards in Antibodies To Things Deck (48)
Ds-DNA (double stranded DNA)
MOST highly specific for SLE
What Ab can you order with a high sensitivity for SLE?
*a/w high specificity for SLE
*predicts lupus nephritis
*correlates with disease severity
What antibody do you order which is a/w lupus nephritis in SLE?
Double-stranded DNA or Anti-Sm
*also anti-Smith does as well
*ds-DNA has a high specificity for SLE, predicts disease severity, correlates with early/severe disease
A/w lupus nephritis, highly specific for SLE
*So is anti-dsDNA
Anti-rRNP (U1 RNP)
R-RNP - Highly specific for neuropsychiatric LE *per Jain
U1 RNP - Highly specific for MCTD *per Hocker
What antibody do you test if you are suspicious for neuropsychiatric LE?
SJOGRENS!(Most strong association)
Neonatal lupus/congenital heart block
What antibodies do you order to check for SCLE
*also a/w congenital heart block
Anti-SSA,Anti-SSB is the same Ab as what?
*checks for SCLE/neonatal lupus/congenital heart block/ AND Sjogrens
Antibody to check for neonatal lupus?
Anti-Ro/La (same thing as SSA/SSB)
Strongest Ab a.w Sjogrens
*MOST SPECIFIC -Anti fodrin
*which are also a/w SCLE/neonatal lupus
What two diseases is anti-Ro/La a/w?
SJOGRENS (strong) (sidenote* anti-fodrin is most specific)
*also can see in SCLE but mostly MCTD
Drug induced SLE
Antibody indicating drug induced SLE/SCLE
SLE with polymyositis
Antibody for drug induced polymyositis
Increased risk of SLE in DLE
What antibody would you order in a DLE patient to assess their possible risk for SLE?
Anti-dsDNA is most specific test for SLE
Anti-ssDNA is risk of SLE within a DLE patient
Test for antiphospholipid syndrome in SLE
Most SPECIFIC for Sjogrens!!!
*also strong is anti-Ro/La
Which Ab a/w systemic disease and lymphoma in Sjogrens
Anti Ro (other Ab associated w Sjogrens are Ro/La and Fodrin)
Same thing as DNA-topoisomerase I (seen in systemic sclerosis)
Anti-Scl-70 is the same this as what antigen
DNA topoisomerase I. (Seen in severe systemic sclerosis)
Ab most strongly a/w diffuse skin disease in systemic sclerosis
Anti-Scl-70 (DNA topoisomerase I)
Ab a/w CREST