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Flashcards in Drugs Deck (207)
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1

What is the active metabolite of azathioprine?

6-mercaptopurine (6MP), and endpoint active metabolite is thioguanine if it goes through the HPRT pathway (the bad one)

2

Generic name for Imuran

Azathioprine

3

Purine analogue, blocks purine biosynthesis

Imuran (Azathioprine)

And also Cellcept is one as well

4

Which phase of the cell cycle is blocked by azathioprine?

S phase

5

Why do you check a TMPT on a patient you are about to start on Imuran?

Before you start someone on Imuran (Azathioprine), you should check a TMPT level because if they have a hereditary deficiency in the enzyme then the drug will be metabolized down the HPRT pathway which gives the person bone marrow suppression= bad

6

What drug do you not want someone to be on while they are on imuran?

Allopurinol (inhibits the TMPT and XO pathway)

7

Which enzyme does Cellcept inhibit?

Inosine monophosphate dehydrogenase (IMPDH)

8

How does Cellcept treat things?

Inhibits purine synthesis of T and B cells in particular, because these cells do NOT HAVE A PURINE SALVAGE PATHWAY!!!

9

Nitrogen mustard derivative which blocks DNA cell cycle synthesis

Cyclophosphamide

10

Name a few side effects of Cyclophosphamide

HEMORRHAGIC CYSTITIS
Azoospermia
Pulmonary fibrosis
Alopecia

11

What is cyclophosphamide (Cytoxan) the treatment of choice for?

Wegeners granulomatosis

12

What is the drug of choice to treat Wegeners?

Cyclophosphamide

13

What dose Cyclosporine inhibit?

T cell synthesis

14

How does cyclosporine work?

Inhibits cyclophilin - which blocks calcineurin - which decreases NFAT - which decreases IL-2

15

Gingival hyperplasia

Cyclosporine

16

Which organ do you watch out for when prescribing cyclosporine?

Kidneys! (Nephrotoxic)

17

Which drug is metabolized by Cytochrome P450 3A4

Cyclosporine

18

What cytochrome is Cyclosporine metabolized by?

Cytochrome P450 3A4

19

Name 4 drugs that will increase renal toxicity risk of Cyclosporine

NSAIDS
Aminoglycosides
Vancomycin
Amphotericin B

20

Name 4 Cytochrome p450 inducers?

Carbamazepine
Phenytoin
Phenobarbital
Rifampin

21

What HTN med do you give if you get Cyclosporine induced HTN?

Israpidine

22

What is the maximum amt of time you can be on Cyclosporine?

One year

23

Max Cyclosporine dose per day

5mg/kg

24

What do you use Thalidomine to treat?

Erythema nodosum leprosum

25

What does Imiquimod bind?

TLR-7

26

Thymidyline Kinase

The enzyme that acyclovir uses to work

27

What enzyme does acyclovir use to work?

Thymidyline kinase

28

What drug do you use to treat scabies in pregnant women

Precipitated sulfur

29

How does permethrin work?

Blocks sodium channels, paralyzing the mite

30

How does ivermectin work?

Blocks chloride channels, paralyzing the parasite