Flashcards in Drugs Deck (207)
What is the active metabolite of azathioprine?
6-mercaptopurine (6MP), and endpoint active metabolite is thioguanine if it goes through the HPRT pathway (the bad one)
Generic name for Imuran
Purine analogue, blocks purine biosynthesis
And also Cellcept is one as well
Which phase of the cell cycle is blocked by azathioprine?
Why do you check a TMPT on a patient you are about to start on Imuran?
Before you start someone on Imuran (Azathioprine), you should check a TMPT level because if they have a hereditary deficiency in the enzyme then the drug will be metabolized down the HPRT pathway which gives the person bone marrow suppression= bad
What drug do you not want someone to be on while they are on imuran?
Allopurinol (inhibits the TMPT and XO pathway)
Which enzyme does Cellcept inhibit?
Inosine monophosphate dehydrogenase (IMPDH)
How does Cellcept treat things?
Inhibits purine synthesis of T and B cells in particular, because these cells do NOT HAVE A PURINE SALVAGE PATHWAY!!!
Nitrogen mustard derivative which blocks DNA cell cycle synthesis
Name a few side effects of Cyclophosphamide
What is cyclophosphamide (Cytoxan) the treatment of choice for?
What is the drug of choice to treat Wegeners?
What dose Cyclosporine inhibit?
T cell synthesis
How does cyclosporine work?
Inhibits cyclophilin - which blocks calcineurin - which decreases NFAT - which decreases IL-2
Which organ do you watch out for when prescribing cyclosporine?
Which drug is metabolized by Cytochrome P450 3A4
What cytochrome is Cyclosporine metabolized by?
Cytochrome P450 3A4
Name 4 drugs that will increase renal toxicity risk of Cyclosporine
Name 4 Cytochrome p450 inducers?
What HTN med do you give if you get Cyclosporine induced HTN?
What is the maximum amt of time you can be on Cyclosporine?
Max Cyclosporine dose per day
What do you use Thalidomine to treat?
Erythema nodosum leprosum
What does Imiquimod bind?
The enzyme that acyclovir uses to work
What enzyme does acyclovir use to work?
What drug do you use to treat scabies in pregnant women
How does permethrin work?
Blocks sodium channels, paralyzing the mite