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Flashcards in Cell Structure Deck (123)
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1

What special structure is present in the stratum granulosum that binds keratin filaments together?

Keratohyaline granules (they are filled with histidine and cysteine rich proteins which bind the keratin filaments together)

2

What level of the epidermis are keratohyaline granules found?

Stratum granulosum

3

What substances do keratohyaline granules (present in stratum granulosum) contain?

Profilaggrin, loricrin, and involucrin

4

Where is fillagrin located?

Stratum Granulosum

5

What does filaggrin do?

Binds Keratin (like K 6/16) intermediate filaments and organizes into fibrils (like the glue that binds the keratins)

6

Where is filaggrin located?

In the keratohyaline granule in the stratum granulosum

7

Keratins found in the stratum granulosum

K2 and K10 (K11)

8

What enzyme crosslinks peptide bonds in the cornified envelope to make it into the insoluble compound y-glutamic lysine isopeptide bonds

Transglutaminase

9

What is the major protein component of the cornified envelope?

Loricrin

10

What enzyme crosslinks all the protein peptide bonds loricrin and involucrin to make the cornified envelope?

Transglutaminase 3

11

What are the two major proteins that make up the cornified envelope?

Involucrin and loricrin (fillagrin is the glue)

12

Which cornified envelope protein is the substrate for transglutaminase

Involucrin (this is the one that is upregulated in psoriasis)

13

What two cell proteins are upregulated in psoriasis, and which is downregulated?

Involucrin and K6/16 is upregulated
Loricrin is downregulated

(P5 in Jain)

14

Substrate for transglutaminase in the cornified envelope

Involucrine

15

Upregulated in all layers in Psoriasis except basal

Involucrin

16

Components of the basal layer (as a part of the DEJ)

Keratins K5/K14

17

K5/K14

Basal layer keratinocytes, part of the BMZ complex/DEJ

18

Hemidesmosome anchoring filament proteins

BPAG 1
BPAG 2 (Collagen XVII)
Plectin
Alpha-6, beta-4 integrin
Tetraspan CD151
Laminin 332 (Laminin 5)

19

Collagen XVII

Same thing as BPAG II

20

What collagen is found in the lamida Lucida/basal layer

Collagen XVII - same thing as BPAG II

21

Plectin

A Heim-desmosome anchoring filament protein - found in the basal layer/lamida lucida along with BPAG I,II, integrin, and laminin 5 (332)

22

What type of collagen is found in the lamida densa?

Collagen IV

23

Type IV collagen found where?

Lamina Densa

24

Major components of lamina densa?

Type IV Collagen
Heparin Sulfate proteoglycans
Laminin 311 (6) Laminin 511 (10)
Nitrogen
(Also tecnically some of laminin 5(332)

25

Major components of the sublamina densa

Type VII collagen
Type III collagen
Type I collagen
Elastin
Fibrillin
Latent TGB-beta proteins

26

Where is type VII collagen found?

Sublamina densa

27

Major protein comprising Anchoring Fibrils?

Type VII Collagen

28

What are anchoring fibrils made of and where are they found?

Made of Type VII collagen and they are found in the sublamina densa

29

What protein connects the lamida lucida to the lamina densa?

Laminin 332 (Laminin 5)

30

Members of the plakin family

Plectin
BPAG 1
BPAG 2
Envoplakin
Desmoplakin
Periplakin