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CNS I > Antidepressant Drugs > Flashcards

Antidepressant Drugs Flashcards

(PH-1) List the prototype antidepressant drugs for the following classes of drugs: tricyclics, SSRI’s, SNRI’s, and MAO inhibitors. (PH-2) Describe the mechanism of action for the prototype tricyclic, SSRI, SNRI, and MAO inhibitor antidepressants, list their appropriate clinical uses, and their major side effects and contraindications. PH-3) Describe the mechanism of action of amoxapine, bupropion, mirtazapine and trazodone, list their appropriate clinical uses, and their major side effects and (88 cards)

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1
Q

TCA prototypes (3)

A

inipramine, amitriptyline, clomipramine

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2
Q

TCA MOA

A

block 5-HT, and NE reuptake

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3
Q

side effects of TCA

A

anticholerginic (dry mouth, blurred vision, constpation, urinary retention, worseing glaucoma, delerium)

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4
Q

current clinical uses of TCA

A

less for depression, more for sleep and neuropathic pain

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5
Q

toxicity of TCAs

A

can cause cardiac conduction problems

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6
Q

MOA of MAOis

A

blocks the action of intracellular monoamine oxidase

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7
Q

prototype MAOi (3)

A

tranylcypromine, phenelzine, isocarboxazid

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8
Q

length of effect of MAOi after drugs are stopped

A

2 weeks

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9
Q

main cause for ineffectiveness of antidepressant meds

A

insufficent time taking meds and/or inadequate doses

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10
Q

time to effect of antidepressant

A

4-8 weeks

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11
Q

possible lethal SE of MAOi

A

hypertensive crisis and sertonin syndrome

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12
Q

foods that can cause hypertensive crisis with MAO

A

cheese,beer, chanti, femented sausages, sauerkraut, soy sauce

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13
Q

sx of serotonin syndrome

A

tremors, hyperreflexia, clonus, fever, agitation, diaphoresis, possibly death

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14
Q

MAO can interact with which drugs to cause serotonin syndrome

A

serotonic ADs, some opioids (fentanyl, tramadol)

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15
Q

parkinson’s drugs that interact with MAOi

A

selegiline, rasagiline

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16
Q

antibiotics that interact with MAOi

A

isoiazid and linezoid

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17
Q

non-lethal SE of ADs

A

orthostatic hypotension, sexual dysfunction, weight gain

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18
Q

clinical use of MAOi

A

refractory depression

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19
Q

MOA of SSRI

A

bock the presynaptic serotonin reuptake pump

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20
Q

SSRI protypes (6)

A

fluoxetine, setralline, paroxetine, fluvoxamine, citalopram, escitalopram

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21
Q

SE of SSRIs

A

agitation, insommnia, sexual dysfunction, n/v

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22
Q

advantages of SSRI

A

cheap, few side effects, more effective

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23
Q

longest t 1/2 SSRI

A

fluoxetine,

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24
Q

SSRI that can be used for people who tend to skip doses

A

fluoxetine

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25
time after stopping that fluoxetine can interact with other drugs
up to 5 weeks
26
SSRI that tends toward nausea
setraline
27
SSRI that is most sedating
paroxetine
28
drug that can cause severe withdrawal (2)
paroxetine, SNRIs
29
drug that can cause prolonged QT intervals
citalopram
30
SSRI that can interact with PPIs
citalopram
31
SSRI that can cause problems with CYP2C19
citalopram
32
SNRI prototypes (2)
venlafaxine and duloxetine
33
MOA of SNRI (moderate doses)
inhibits 5-HT and NE
34
MOA of SNRI (high doses)
inhibits reuptate of 5-HT, NE and dopamine
35
non AD uses of duloxetine
diabetic neuropathy, fibromyalgia, stress urinary incontenince
36
SE of SNRI
(noradrenigic) insomnia, sweating, dry mouth, constipation, worseing of glaucoma
37
starting SE of SNRI
nausea
38
can cause withdrawal sx in a single dose
SRNIs
39
nefazodone/trazodone MOA
block 5-HT2 receptors
40
advantages of nefazodone/trazodone over SSRI
no sexual dysfunction, agitation or sleep dyfunction issues
41
nefazodone toxicity
liver failure (rare)
42
rare, but serious SE of trazodone
priapism
43
buproprion MOA
inhibits NE and DA uptake
44
helps with nicotine cessation
burprprion
45
advantages of buproprion
no sexual side effects, has stimulant effect
46
contraindicated in people with seziures, eating disordersm or EtoH/benzo withdrawal
buproprion
47
SE of buproprion
constipation, dry mouth, insomnia, sweating
48
mirtazapine MOA
blocks presynnaptic a-2 receptors on 5HT neurons - increasing 5-HT at synapse
49
advantages of mirazapine
less sexual/sleep.agitation effects and less nausea
50
SE of mirazapine
sedating and weight gain
51
AD used in oncology and in geriatric pts
mirazapine
52
uses of ECT
severe-drug resistant depression, bipolar and schizophrenia
53
remission rate in ECT
86%
54
potent CYP2D6 inhibitors
paroxetine and fluxetine
55
cancer drug that can interact with SSRIs
tamoxifen
56
SSRI indicated for kids
fluoxetine
57
AD for panic disorder
TCA
58
AD for OCD
clomipramine
59
AD for ADHD
desipramine
60
AD for panic disorder.social phpbia
MAOi
61
AD used for premenstral dysphoric disorder/bullimia. trichotillimania
SSRI
62
AD drug for neuropathy and fibromyalgia
SNRI
63
amine hypothesis of depression
functional decrease of NT amines (NE, serotonin) causes depression
64
fluoxetine + (lithium/TCA/warfarin)
increased levels of second drug
65
fluvoxamine + (alprazolam, theophylline, TCA, warfarin)
increased levels of second drug
66
MAOis + (sympathopmimetics+tyramine+SSRI)
hypertensive crisis/serotonin syndrome
67
nefazodone+ alprazolam/triazolam
increased levels of second drug
68
paroxetine + procyclidine, theophylline/TCA/warfarin
increased levels of second drug
69
sertraline +(TCA/warfarin)
increased effects of both
70
TCA+ CNS depressents
additive CNS depression
71
TCA+ central acting HBP meds
decreased effect of HBPs
72
Causes dose dependent hypertension
Venlafaxine
73
Imipramine class
TCA
74
Amitripyline class
TCA
75
Desipramine class
TCA
76
Nortriptyline class
TCA
77
Clomipramine
TCA
78
Amoxapine
TCA
79
Setraline class
SSRI
80
Fluoxetine
SSRI
81
citalopram
SSRI
82
Venlafaxine
SNRI
83
Duloxetine
SNRI
84
Phenelzine class
MAOI
85
Tranylcypromine
MAOI
86
Isocarboxazid
MAOI
87
Selegiline
MAOI
88
ANTIDEPRESSANT that causes weight gain
Mirtazapine

CNS I (36 decks)

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