schizophrenia Flashcards

•Describe positive and negative symptoms seen in schizophrenia •Differentiate between good and bad prognostic signs in schizophrenia •List the most commonly reported neuropsychological deficits (dorsolateral prefrontal cortex and related executive function) and imaging findings (enlarged ventricles) •Differentiate between schizophreniform disorder, brief psychotic disorder, schizoaffective disorders, shared psychotic disorder and schizophrenia (see additional handout from Dr. Spollen (42 cards)

1
Q

characteristic sx of schizophrenia

A

delusions, hallucinations, odd behavior, lauguage disturbance, normal memory and cognition

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2
Q

delusions in schizophrenia

A

false, unreasonable beliefs
often elaborate and cultural
not culturally bound beliefs
often paranoid

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3
Q

typical hallucinations in schizophrenia

A

auditory (voices)

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4
Q

neologism

A

made up words

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5
Q

echolalia

A

repeating words

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6
Q

incidence of schizophrenia worldwide

A

1%

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7
Q

age of schizophrenia onset in males

A

15-25

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8
Q

age of schizophrenia onset in females

A

20-30

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9
Q

indocators of good progress in schizophrenia (5)

A

doing well before illness
abrupt onset
later onset
prominent confusion
FMX of mood disorder

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10
Q

indicators of poor progress in schizophrenia

A

gradual onset
withdrawn, odd before illness
early onset
FMX of psychosis

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11
Q

environmental potential cause of schizophrenia

A

neuroimmunovirologia

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12
Q

non genetic risk factors for schizophrenia

A

season of birth
delivery complications
advanced parental age
drug use

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13
Q

risk of schizophrenia if a parent has it

A

10%

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14
Q

risk of schizophrenia if both parents have it

A

50%

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15
Q

risk of schizophrenia if an identical twin has it

A

50%

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16
Q

dx criteria of schizophrenia

A

2 or more sx each active for one month
continuous signs of disturbance for 6 months with at least 1 month of active sx

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17
Q

sx of schizophrenia criteria

A

hallucinations
delusions
disorganized speech
catatonia or grossly disorganized behavior
negative sx

18
Q

negative sx of schizophrenia

A

affective flattening, alogia, avolition

19
Q

subtypes of schizophrenia

A

paranoid
catatonic
disorganized
undifferentiated

20
Q

sx of paranoid schizophrenia

A

prominent delusions
later onset
high functioning
logical and coherent laungauge

21
Q

type of schizophrenia that responds to ECT

22
Q

most common subtype of schizophrenia

A

undifferentiated

23
Q

positive sx of schizophrenia

A

delusions, hallucinations

24
Q

DDX of schizophrenia

A

cocaine/stimulant/PCP intox
organic brain disease
bipolar, schizoaffective, delusional disorder

25
schizoaffective disorder description
schizophrenia +prominent mood disorders at times
26
way to distinguish psychosis in schizophrenia from bipolar
bipolar is not chronic psychosis and more likely to normalize
27
difference between deulsional disorder and schizophrenia
prominent delusions w/o hallucinations or lauguage disturbance usually starts later in life uncommon often paranoid
28
meets schizophrenia sx criteria but only lasting one month
brief psychotic disorder
29
meets schizophrenia sx but less than 6 months
schizophremiform disorder
30
physical brain findings in schizophrenia
increased ventricles shrunken thalmus frontal lobe involvement
31
neurotransmitter in schizophrenia
dopamine (too much)
32
micropathology in schizophrenia
fewer, compact cortical neurons disoranized cortex layers less dendritic arborization less glia
33
almost 100% of schizophrenics use this drug
nicotine
34
comorbidities in schizophrenia
smoking related illnesses, diabetes, suicide
35
low potency 1st gen antipsychotic
chorpromazine
36
high potency 1st gen antipsychotic
haloperidol
37
second gen antipsychotics
olanzapine, aripprazole
38
SE of olanzapine
weight gain, diabetes, sedation
39
SE of clozapine
agranulocytosis, seziures, weight gain
40
current "stand-out" antipsychotic for schizophrenia
clozapine
41
lobe involved in positive schizophrenia sx
limbic
42
lobe involved in negative schizophrenia sx
frontal