herpes virus

Question 1

describe the Herpes virus

Answer 1

2x stranded DNA
Capsid
Glycoprotein envelope

Question 2

the glycoprotein envelope makes the herpes virus….

Answer 2

sensitive to heat (labile)

Question 3

mediates attachment of the HSV to host cells

Answer 3

glycoproteins whoch act as receotirs

Question 4

targets for herpes therapy

Answer 4

DNA polymerase and thymidine kinase

Question 5

generally causes lesions “above the waist”

Answer 5

HSV-1

Question 6

generally causes lesions “below the waist”

Answer 6

HSV-2

Question 7

location of HSV latency

Answer 7

sensory neurons of neural ganglia

Question 8

can activate latent HSV infection

Answer 8

UV exposure, menstration, fever, infection, stress and some drug interactions

Question 9

immune defense to intial HSV infection

Answer 9

interferon and NK

Question 10

immune defense to spread of HSV infection after intial phase

Answer 10

T cells, activated macrophages

Question 11

HSV usually aquired by age 2

Answer 11

HSV-1

Question 12

HSV often aquired after sexual maturity

Answer 12

HSV-2

Question 13

natural host of HSV

Answer 13

humans only

Question 14

epidemiologically associated with cervical cancer

Answer 14

HSV-2

Question 15

causes genital herpes

Answer 15

1 and 2

Question 16

causes gingivostomastitis

Answer 16

1

Question 17

causes keeratocinjunctivitis

Answer 17

1

Question 18

causes cutaneous herpes

Answer 18

1 and 2

Question 19

causes encephalitis

Answer 19

1

Question 20

causes neonatal herpes

Answer 20

2

Question 21

causes meningioencphalitis

Answer 21

2

Question 22

causes herpes labilalis (cold sores)

Answer 22

1

Question 23

causes childhood pharyngitis

Answer 23

1

Question 24

Herpes whitlow def

Answer 24

sores on the hands of dentists

Question 25

signs of congentital herpes at birth

Answer 25

hepatospenomegaly, microencephaly, vesicles, eye lesions,

Question 26

will indicate poor prognosis in neonatal herpes

Answer 26

neurological signs

Question 27

microscopic findings of herpes lesions

Answer 27

multinucleated giant cells in tzank smears and intranuclear inclusion bodies

Question 28

4 ways to lab diagnose HSV

Answer 28

Microscopy Cell culture (immunoflorence or DNA assay) PCR Serology

Question 29

standard anti-herpes viral drug

Answer 29

acyclovir

Question 30

target of acyclovir

Answer 30

thymadine kinase

Question 31

MOA of acyclovir

Answer 31

nucleoside analog, causes errors in DNA replication or RNA transcription or indirect inhibition od DNA polymerase

Question 32

used against acyclovir resistant HSV

Answer 32

foscarnet

Question 33

why anti-virals cannot eradicate latent infection

Answer 33

no DNA replication during that time

Question 34

main route of VZV transmission

Answer 34

respiratory

Question 35

reactivation of the latent VZV infection leads to

Answer 35

herpes zoster

Question 36

latent VZV resides in the...

Answer 36

sensory root ganglion

Question 37

sx of varicella

Answer 37

malise, skin rash, anorexia, listlessness

Question 38

adults with varicella may develop

Answer 38

VZV pneumotitis

Question 39

congenital varicella may lead to

Answer 39

skin scarringm hypoplastic limbs, eye abnormalities and CNS involvement

Question 40

most significant clincal problem with herpes zoster

Answer 40

post-herpetic neuralgia

Question 41

syndrome from kids taking aspirin during chicken pox

Answer 41

Reye's

Question 42

recommended age for herpes zoster vaccination

Answer 42

60 and older

Question 43

drug treatment for adult varicella and zoster

Answer 43

acyclovir