Antidiabetics 1 W3

Question 1

Pharmacological target of antidiabetics

Answer 1

1. Pancreas
   Drugs: sulfonylureas, GLP-1 receptor agonists, DPP-4 inhibitors
2. GIT
   Drugs: GLP-1 receptor agonists, DPP_4 inhibitors
3. Liver
   Drugs: metformin
4. Kidney
   Drugs: SGLT2 inhibitors

Question 2

Half life of GLP-1

Answer 2

Short

<2mins

rapidly inactivated by DPP-4

Question 3

What do DPP-4 inhibitors do

Answer 3

Increase glucose-dependant insulin secretion

Question 4

What does inhibition of DPP-4 do

Answer 4

Decreases breakdown of GLP-1 so it can perform it biological actions longer

Question 5

What is DPP-4

Answer 5

Enzyme that breaks down GLP-1