Disorders of sexual & reproductive function W4 Flashcards
(12 cards)
Tests of gonadal function
Detailed history and physical examination
Test blood levels for oestrogen/testosterone, LH, FSH, GNRH and prolactin
Imaging, if glands of suspected
Male hypogonadism symptoms
Subfertility
Poor libido
Impotence
Loss of secondary sexual hair
Causes of ED
Cardiovascular disease - can be an early sign of CVD
Diabetes
Hypertension
High cholesterol
Obesity
Stress, anxiety, depression
Treatment of ED
Lifestyle changes
Medication: sildenafil, Tadalafil
Homeotherapy
Devices
Physiological therapy
Sildenafil MOA
Sildenafil is a PDE5 inhibitor
During sexual stimulation, nitric oxide is released into the penis
The nitric oxide increases cyclic GMP
This causes the relax of smooth muscles and increased blood flow leading to an erection
PDE five breaks down CGM P ending the direction
Sildenafil blocks PDE5 allowing CGM P to remain active longer prolong direction
Sildenafil molecular mechanism
Mimics CGM P allowing it to bind to the PDE five enzyme
Prostate symptoms score
Questionnaire to assess the severity
Seven questions for seven symptoms scored from 0 to 5 to give a total range of 0 to 35
0–7 = mild
8–19 = moderate
20–35 = severe 
What is hypogonadism?
Where the gonads produce insufficient sex hormones
Primary hypogonadism
In the gonads themselves
Failed to produce enough hormone
Secondary hypogonadism
Is in the hypothalamus or pituitary glands?
Don’t send enough signals to the gonads.
Causes of hypogonadism
Genetic
Damage
Chronic illness
MEDS/chemo
Treatment of hypogonadism
Testosterone/progesterone
Address underlying causes
Fertility treatment if desired
