Antifungals Flashcards Preview

Year 2 Pharmacology > Antifungals > Flashcards

Flashcards in Antifungals Deck (12):
1

Anti fungal drugs target

Fungal specific processes/structurs

2

The fungal CW has

Skeletal and matrix components

3

Skeletal CW components

Glucan
Chitin

4

Current anti fungals that target cell wall are

Inhibitors of b1-3 glucan biosynthesis

5

What is the target for the currently used anti fungals

Pm

6

Pm in fungal cells contain

Ergosterol (without this fungal cells will not survive)

Those of human cells contain cholesterol

7

Echinocandins

Caspofungin
Micafungin

Inhibit the enzyme b1-3 glucan synthetase
Block synthesis of b1,3 glucan
Drugs are fungicidal

8

Polyene anti fungals

Amphotericin b
Nystatin

Bind to resident Ergosterol

Prolong use = kidney failure

9

Mycoses

Disease caused by fungi

10

Azoles anti fungal

Imiadzoles
Triazoles

Inhibit enzyme lanosterol c-14
Blocks Ergosterol

11

Allylamines

Teraiafine
Amorolfine

Inhibit earlier step Azoles

12

Flucytosine

DNA RNA synthesis

Used with Azoles

Fungal cell turn into 5-fu which inhibits NA synthesis