Arthritis Drugs - NSAIDs and Analgesics Flashcards Preview

Year 2 Pharmacology > Arthritis Drugs - NSAIDs and Analgesics > Flashcards

Flashcards in Arthritis Drugs - NSAIDs and Analgesics Deck (31):
1

Loss of cartilage and bone from articulating surfaces

Osteoarthritis

2

Systemic auto-immune disorder, may affect other tissues

Rheumatoid Arthritis

3

Celecoxib
Etoricoxib

Cox2 Inhibitors

4

Cox2 Inhibitors

Used mainly in patients at high risk of GI side effects

5

Side effects of Cox2 Inhibitors

Headaches, dizziness, skin, rash, oedema

6

Synthetic Prostaglandins

Misoprostol

7

Misoprostol

Given along side NSAID
Preserves mucous lining of GI tract
Protects against ulceration
Stimulating abortion

8

Side effects of Misoprostol (synthetic PG)

Diarrhoea, Vaginal Bleeding

9

Early Cox 2 Inhibitor

Meloxican
Rotecoxib

10

Side effects of early Cox2 Inhibitors

CV complications

11

NSAID

Asprin

12

Asprin

Rapidly absorbed in stomach
Displaces warfarin bound to plasma protein - ^ plasma warfarin
Negatively charged

13

Side effects of NSAID

Gastric ulcers
Impaired co-agulation
GI bleeding
CV events
May induce asthma attack
Skin rash
Kidney damage
Liver damage

14

Analgesic/Antipyretic

Paracetamol

15

Paracetamol

Not a NSAID
No anti-inflammatory effect

16

Side effects of paracetamol

Kidney damage
Liver damage

17

Oesteoarthritis treatmen t

Strontium Renelate

18

Strontium Renelate

Osteoarthritis
Promotes osteoblasts
Inhibits osteoclast activity
Reduces pain
Prevention of serve fractures

19

Side effects of Strontium Renelate (osteoarthritis)

Risk of MI
Risk of thrombotic events

20

Glucosamine Sulphate

Major constituent of ECM
Present in cartilage + synovial fluid

21

Hydiocortisone
Corticosterone
Aldosterone

Natural steroids

22

Celecoxib is a ? inhibitor

COX 2 selective

23

Celecoxib is thought to have a reduced risk of causing..

Gastric Ulcer

24

Common side effect of cyclophosphamine treatment

Haemorrhagic cystitis

25

What is the proposed mechanism for the gastric bleeding associated with use of NSAIDs?

Inhibition of COX 1

26

Methotrexate is a cytotoxic drug used to treat rheumatoid arthritis, its mech of action reduces synthesis of what?

Folic acid

27

Examples of NSAID's

Ibuprofen
Aspirin
Diclofenac
Meloxicam

28

Examples of Corticosteroids

- Mixed guco/minercoricoid
Prednisolone
- Glucocorticoid
Dexamethasone, Betamethasone, Bedamethasone, Budenoside
-Minercocorticoid
Fludrocortisone

29

Examples of immnosupressants

Ciclosporin
Azothioprine
Methotrexate
Leflunomide
Cyclophosphaide

30

Sulfasalazine
Pencillamine
Gold Compounds
Anti malarials

are examples of

Disease-modifying anti-rheumatoid drugs (DMARDS)

31

Examples of anticytokines

Eternercept
Inflixiab
Rituximab
Abatacept