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Flashcards in Antifungals/Antiparasites Deck (24):
1

mechanism of ampho B

binds ergosterol and forms membrane pores that allow electrolyte leakage

2

should supplement ___ and ___ in pts taking ampho B

K+, Mg 2+

3

SEs of ampho B

- fever, chills
- nephrotoxicity --> hypokalemia, hypomagnesemia --> arrythmias
- anemia
- IV phlebitis

(can prevent with hydration and using liposomal ampho B)

4

mechanism of nystatin

binds ergosterol and forms membrane pores that allow electrolyte leakage

5

clinical use of nystatin

only used topically - oral/vaginal candidiasis, diaper rash

6

mechanism of flucytosine

converts to 5-FU via cytosine deaminase and prevents DNA/RNA synthesis

7

clinical use of flucytosine

used with ampho B, particularly in C. neoformans meningitis

8

PPx for prior C. neoformans meningitis

fluconazole

9

SEs of flucytosine

BM suppression

10

mechanism of -azole antifungals

inhibit fungal ergosterol synthesis by inhibiting 14-a-demethylase, which leads to cell membrane breakdown

11

itraconazole ____ steroid hormone synthesis

increases

12

ketoconazole ____ steroid hormone synthesis

decreases

13

mechanism of terbinafine

inhibition of squalene epoxidase, which helps produce ergosterol for cell membrane

14

clinical use of terbinafine

dermatophytoses esp. onchomycosis

15

SEs of terbinafine

hepatotoxicity, taste disturbances

16

mechanism of -fungin drugs

inhibit production of B-glucans thereby inhibiting cell wall synthesis

17

SEs of -fungin drugs

histamine-induced flushing

18

mechanism of griseofulvin

interferes with microtubule function and disrupts mitosis

19

griseofulvin deposits in ____-containing tissues only, so it can only be used for:

keratin, superficial infections/dermatophytes

20

SEs of griseofulvin

carcinogenic, teratogenic, disulfiram-like reaction

21

drugs used for scabies/lice and their mechanisms of action

- permethrin - neuronal membrane depolarization via Na+ channels
- malathion - AChesterase inh
- lindane - GABA antagonist causing neurotoxicity

Treat Pesty Mites and Louse because they NAG you.

22

mechanism of bendazoles

microtubule inhibitor

23

mechanism of chloroquine

blocks detox of heme into hemozoin so heme accumulates and is toxic to the plasmodia

24

SEs of chloroquine

retinopathy, pruritis