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Flashcards in Neuro Drugs Deck (52):
1

mechanism of ethosuximide

blocks thalamic T-tyle Ca 2+ channels

2

use of ethosuximide

first-line for absence seizures

3

notable SEs of ethosuximide

Stevens-Johnson syndrome

4

mechanisms of (-azepam) drugs

benzos - increase frequency of opening of GABA-mediated Cl channel

5

use of (-azepam) drugs

first-line for acute status epilepticus

6

mechanism of phenytoin

Na channel inactivation

7

use of phenytoin

- first-line treatment of tonic-clonic
- first-line prophylaxis for status epilepticus
- can also be used for simple, complex

8

notable SEs of phenytoin

- teratogen
- Stevens-Johnson
- peripheral neuropathy

9

mechanism of carbamazepine

Na channel inactivation

10

use of carbamazepine

- first-line for simple, complex, and tonic-clonic
- trigeminal neuralgia

11

notable SEs of carbamazepine

- hepatotoxicity
- teratogen
- SIADH
- Stevens-Johnson
- blood cell dyscrasias

12

mechanism of valproic acid

- Na channel inactivation
- inhibits GABA transaminase - increased GABA concentration

13

use of valproic acid

- first line for tonic-clonic
- can be used for simple, complex, absence

14

notable SEs of valproic acid

- hepatotoxicity
- neural tube defects
- tremor
- weight gain

15

mechanism of gabapentin

inhibits VG Ca 2+ channels

16

use of gabapentin

- peripheral neuropathy
- postherpetic neuralgia

17

mechanism of phenobarbital

increase duration of opening of GABA-mediated Cl channels

18

mechanism of topiramate

- blocks Na channels
- increases GABA action

19

notable SEs of topiramate

kidney stones

20

use of topiramate

migraine PPx

21

mechanism of lamotrigine

blocks VG Na channels

22

notable SEs lamotrigine

SJS

23

mechanism of levetiracetam

unknown

24

What is the most common cause of complex partial seizures in adults?

mesial temporal sclerosis

25

How do you treat the seizures of eclampsia?

MgSO4

26

What drug is first line for absence seizures?

ethosuximide

27

What drug is first line for status epilepticus?

IV lorazepam or diazepam

28

What drug is first line for PPx of status epilepticus?

phenytoin

29

What drugs are first line for tonic-clonic seizures?

- phenytoin
- carbamazepine
- valproic acid

30

What drug is first line for simple and complex seizures?

carbamazepine

31

How to treat OD of benzos?

flumazenil

32

How to treat alcoholic DT?

chlordiazepoxide or other benzo

33

mechanism of baclofen

inhibits GABA receptors at spinal cord level to induce muscle relaxation

34

mechanism of cyclobenzaprine

centrally acting muscle relaxant

35

mechanism of sumatriptan

5-HT 1B/1D agonists to induce vasoconstriction

36

use of sumatriptan

abortive for migraines

37

SEs of sumatriptan

coronary vasospasm (cannot use in CAD or Prinzmetal angina)

38

mechanism of memantine

NMDA receptor antagonist that prevents excitotoxicity

39

use of memantine

Alzheimer dz

40

mechanism of donepezil, galantamine, rivastigmine, tacrine

AChE inh

41

use of donepezil, galantamine, rivastigmine, tacrine

Alzheimer dz

42

mechanism of riluzole

NMDA antagonist that prevents excitotoxicity

43

use of riluzole

ALS - prolongs damage to motor neurons

44

mechanism of bromocriptine

dopamine agonist (ergot)

45

mechanism of pramipexole

dopamine agonist (non-ergot)

46

mechanism of amantadine

- increases DA release
- decreases DA reuptake

47

mechanism of L-DOPA

DA agonist that can cross the BBB

48

mechanism of carbidopa

blocks peripheral conversion of L-DOPA to DA by inhibiting DOPA decarboxylase

49

mechanism of entacapone, tolcapone

COMT inhibitors that prevent peripheral degradation of L-DOPA

50

mechanism of selegiline

MAO-B inh that helps prevent peripheral degradation of L-DOPA

51

mechanism of benztropine

antimuscarinic that improves tremor and rigidity in Parkinson

52

Long-term us of L-DOPA/carbidopa will lead to _____ following administration. This is known as ______.

dyskinesia, on-off phenomenon