Respiratory Drugs Flashcards Preview

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Flashcards in Respiratory Drugs Deck (31):
1

When a drug is inhaled ____ goes to the lungs and ____ is swallowed or absorbed into systemic circulation.

- 10-30%
- 70-90%

2

albuterol mechanism

- B2 agonist - raises cAMP production from adenylyl cyclase
- limits airway edema
- short acting (SABA)

3

salmeterol, formoterol mechanism

- B2 agonist - raises cAMP production from adenylyl cyclase
- limits airway edema
- long acting (LABA)

4

use of albuterol

prn for acute asthma exacerbation

5

use of salmeterol, formoterol

- prophylaxis for asthma with ICS
- alone for COPD
- before exercise to prevent EIA

6

fluticasone, budesonide

inhaled corticosteroids

7

mechanism of fluticasone, budesonide

inactivation of NF-kB which is the transcription factor that induces cytokine production, so inhibits synthesis of cytokines

8

use of fluticasone, budesonide

- 1st line for chronic asthma to decrease airway hyper-responsiveness

9

SEs of fluticasone, budesonide

- topical - oral candidiasis, horseness

10

mechanism of ipatropium

M3 antagonist - prevents ACh binding and bronchoconstriction

11

uses of ipatropium

- asthma
- COPD

12

SEs of iptropium

- dry mouth
- urinary retention
- increased IOP

13

mechanism of montelukast, zafirlukast

leukotriene receptor antagonists

14

mechanism of zileuton

inhibits 5-lipoxygenase, blocks leukotriene synthesis

15

mechanism of omalizumab

monoclonal IgE ab - binds unbound IgE and IgE on mast cells and basophils (prevents mast cell degranulation)

16

use of omalizumab

allergic asthma

17

mechanism of theophylline

- causes bronchodilation by inhibiting phosphodiesterase degradation of cAMP
- adenosine antagonist which causes bronchoconstriction

18

SEs of theophylline

low therapeutic window - GI irritation, seizures, tachycarida

19

mechanism of methacholine

M3 agonist used in bronchial challenge to diagnose asthma

20

______ are preferred in peds instead of ICS.

leukotriene mediators

21

The leukotrienes involved in asthma are:

C4, D4, E4

22

mechanism of (-prost-) drugs: beraprost, epoprostenol, iloprost

prostacyclin analogues that induce vasodilation (pulmonary and systemic arterial vascular beds and prevent platelet aggregation

23

SEs of (-prost-) drugs: beraprost, epoprostenol, iloprost

flushing, jaw pain

24

clinical use of (-prost-) drugs: beraprost, epoprostenol, iloprost

pulmonary HTN

25

mechanism of -sentan drugs: bosentan

competitive endothelin-1 receptor antagonist - prevents vasoconstriction and lowers pulmonary vascular resistance

26

SEs of -sentan drugs: bosentan

hepatotoxicity

27

clinical use of -sentan drugs: bosentan

pulmonary HTN

28

mechanism of sildenafil

PDE5 inhibitor - prevents breakdown of cGMP and so prolongs vasodilation via NO

29

clinical use of sildenafil

ED (oral), pulm HTN (inhaled)

30

mechanism of riociguat

guanalyl cyclase stimulator --> more cGMP --> more vasodilation

31

clinical use of riociguat

pulmonary HTN