Antimycobacterials Flashcards Preview

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Flashcards in Antimycobacterials Deck (12):
1

mechanism of rifampin, rifabutin

inhibit DNA-dependent RNA polymerase

2

Rifampin ____ CYP450 activity, Rifabutin ____ CYP450 activity

speeds up, does not change

3

SEs of rifampin, rifabutin

- hepatotoxicity
- red-orange body fluids

4

mechanism of INH

decreased synthesis of mycolic acids in cell wall

5

INH needs ____ to be converted to active metabolite

bacterial catalase peroxidase (KatG gene) - if under-expressed, can lead to resistance

6

SEs of INH

- hepatotoxicity
- vit B6 def --> peripheral neuropathy, sideroblastic anemia (so give with pyridoxine)
- drug induced SLE
- AG met acid

7

SEs of pyrazinamide

hyperuricemia, hepatotoxicity

8

mechanism of ethambutol

inhibition of arabinosyltransferase which decreases carbohydrate polymerization of mycobacterium cell wall

9

SEs of ethambutol

red-green color blindness

10

Prophylaxis for M. tb.

INH + pyridoxine

11

Treatment of M. tb.

RIPE + pyridoxine

12

Prophylaxis for MAC

azithromycin, clarythromycin, or rifabutin