Antihypertensives Flashcards
A1a-selective blocker used for BPH
Tamsulosin (Flomax)
SE of clonidine
Rebound HTN, sedation, dry mouth
Non-selective Beta-blocker also used for migraine prophylaxis
Propranolol
ACE inhibitors are contraindicated in
pregnancy and with hyperkalemia
Alpha 1selective blockers
Prazosin, terazosin and doxazosin (-AZOSIN ending)
SE of methyldopa
Positive Comb’s test, depression
For rebound HTN from rapid clonidine withdrawal
Phentolamine
Non-selective Alpha1blockers use to treat pheochromocytoma
Phenoxybenzamine
SE of alpha blockers
Orthostatic hypotension (especially with first dose) and reflex tachycardia
IV Drug used Hypertensive Crisis
Nitroprusside
CCB with predominate effect on arteriole dilation
Nifedipine
Arterial vasodilator that works by opening K+ channels
Minoxidil
SE of hydralazine
Lupus-like syndrome
SE of minoxidil
Hypertrichosis
Direct vasodilator of arteriolar smooth muscle
Hydralazine
Methyldopa is contraindicated in
Geriatrics due to its CNS (depression) effects
SE of ACE inhibitors
Dry cough, hyperkalemia
Side effect associated with ACEI but not ARBs
Dry cough
Toxicity caused by nitroprusside and treatment
Cyanide toxicity treated with sodium thiosulfate
SE of CCB
Constipation, edema, and headache
Presynaptic Alpha 2 agonist used in HTN
Clonidine, and methyldopa
Block L-type calcium channel
Calcium channel blockers
SE of beta blockers
Bradycardia, SEXUAL DYSFUNCTION, decrease in HDL, and increase in Triglycerols (TG)
Reduce heart rate, contractility, and O2 demand
Beta-blockers
Cardioselective Beta 1-blockers
Atenolol, acebutolol, and metoprolol
Losartan and valsartan block
AT1 receptors
Beta-blockers should be used cautiously in
Asthma (bronchospastic effects), diabetes (block signs of hypoglycemia) and peripheral vascular disease
Nitroprusside vasodilates
Arteries and veins
Inhibit angiotensin-converting enzyme (ACE)
ACE inhibitors
Captopril and enalapril (-OPRIL ending) are
ACE inhibitors
