Drugs for Tx of Coag Disorders Flashcards
Q
A
Vitamin K dependent anticoagulant
Warfarin (PT)
Antidote to reverse actions of warfarin
Vitamin K or fresh frozen plasma
Thrombolytic used for acute MI and ischemic (non hemorrhagic) CVA
Tissue plasmin activator
Antiplatelet drug reserved for patients allergic to aspirin
Ticlopidine
Thrombolytic that can cause allergic reaction
Streptokinase
Thrombolytics are used for
Pulmonary embolism and DVT
Antidote to reverse actions of heparin
Protamine sulfate
Warfarin is contraindicated in
Pregnancy
Route of administration of warfarin
Oral
SE for ticlopidine
Neutropenia and agranulocytosis
MOA of thrombolytics
Lyse thrombi by catalyzing the formation of plasmin which binds fibrin
Alternative anticoagulant used if HIT develops
Lepirudin
MOA of aspirin
Irreversibly blocks COX1 and COX2
SE of heparin
Heparin induced thrombocytopenia (HIT)
Anticoagulant of choice in pregnancy
Heparin
SE of Aspirin
GI bleeding
Prevents thrombosis in patients with artificial heart valve
Dipyridamole
Effective in preventing TIA’s
Clopidogrel and ticlopidine
SE of tPA
Cerebral hemorrhage
SE of both warfarin and heparin
Bleeding
Agent used to treat MI and to reduce incidence of subsequent MI
Aspirin
Heparin (PTT) increases activity of
Antithrombin 3
Antidote for thrombolytics
Aminocaproic acid
Block glycoprotein IIb/IIIa involved in platelet cross-linking
Abciximab, tirofiban and eptifibatide
Routes of administration of heparin
IV and subQ
