Antiarrythmic Agents

Question 1

Adenosine’s MOA

Answer 1

Activates acetylcholine sensitive K+ channels in SA and AV node

Question 2

DOC for paroxysmal supraventricular tachycardia (PSVT)

Answer 2

Adenosine

Question 3

Anti-arrhythmic with <10 second duration of action

Answer 3

Adenosine

Question 4

Class III antiarrhythmic that exhibits properties of all 4 classes

Answer 4

Amiodarone

Question 5

Antiarrhythmic effective in most types of arrhythmia

Answer 5

Amiodarone

Question 6

Class II antiarrhythmics are

Answer 6

B-blockers

Question 7

Anti-arrhythmics that decrease mortality

Answer 7

B-blockers

Question 8

MOA of class IV antiarrhythmics

Answer 8

Calcium channel blockers

Question 9

Class of anti-arrhythmics that has a pro-arrhythmic effect (CAST trial), therefore are used as last line agents

Answer 9

Class IC (flecainide, propafenone, moricizine)

Question 10

Drug used supraventricular arrhythmias

Answer 10

Digoxin

Question 11

Used intravenously for acute arrhythmias during surgery

Answer 11

Esmolol

Question 12

SE of phenytoin

Answer 12

Gingival hyperplasia

Question 13

Major drug interaction with Quinidine

Answer 13

Increases concentration of Digoxin

Question 14

DOC for management of acute Ventricular arrhythmias

Answer 14

Lidocaine

Question 15

SE of procainamide

Answer 15

Lupus-like syndrome

Question 16

Agent to treat torsades de pointes

Answer 16

Magnesium sulfate

Question 17

DOC for digoxin induced arrhythmias

Answer 17

Phenytoin

Question 18

MOA of class III antiarrhythmics

Answer 18

Potassium channel blockers

Question 19

Specific pharmacokinetic characteristic of amiodarone

Answer 19

Prolonged half-life, up to six weeks

Question 20

Side effect of sotalol

Answer 20

prolongs QT and PR interval

Question 21

Limiting side effect of Quinidine

Answer 21

Prolongs QT interval

Question 22

MOA of class I A (eg. Procainamide), class IB (eg. Lidocaine), and class IC (eg. Flecainide) antiarrhythmics

Answer 22

Sodium channel blockers

Question 23

Antiarrhythmic that exhibits Class II and III properties

Answer 23

Sotalol

Question 24

Other side effects of Quinidine

Answer 24

Thrombocytopenic purpura, and CINCHONISM

Question 25

SE of Amiodarone

Answer 25

Thyroid dysfunction, photosensitivity, skin (blue smurf syndrome), corneal deposits, liver damage and pulmonary fibrosis

Question 26

Life threatening cardiac event that prolong QT leads to

Answer 26

Torsades de pointes