Antiarrythmic Agents Flashcards

1
Q

Adenosine’s MOA

A

Activates acetylcholine sensitive K+ channels in SA and AV node

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2
Q

DOC for paroxysmal supraventricular tachycardia (PSVT)

A

Adenosine

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3
Q

Anti-arrhythmic with <10 second duration of action

A

Adenosine

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4
Q

Class III antiarrhythmic that exhibits properties of all 4 classes

A

Amiodarone

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5
Q

Antiarrhythmic effective in most types of arrhythmia

A

Amiodarone

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6
Q

Class II antiarrhythmics are

A

B-blockers

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7
Q

Anti-arrhythmics that decrease mortality

A

B-blockers

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8
Q

MOA of class IV antiarrhythmics

A

Calcium channel blockers

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9
Q

Class of anti-arrhythmics that has a pro-arrhythmic effect (CAST trial), therefore are used as last line agents

A

Class IC (flecainide, propafenone, moricizine)

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10
Q

Drug used supraventricular arrhythmias

A

Digoxin

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11
Q

Used intravenously for acute arrhythmias during surgery

A

Esmolol

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12
Q

SE of phenytoin

A

Gingival hyperplasia

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13
Q

Major drug interaction with Quinidine

A

Increases concentration of Digoxin

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14
Q

DOC for management of acute Ventricular arrhythmias

A

Lidocaine

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15
Q

SE of procainamide

A

Lupus-like syndrome

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16
Q

Agent to treat torsades de pointes

A

Magnesium sulfate

17
Q

DOC for digoxin induced arrhythmias

A

Phenytoin

18
Q

MOA of class III antiarrhythmics

A

Potassium channel blockers

19
Q

Specific pharmacokinetic characteristic of amiodarone

A

Prolonged half-life, up to six weeks

20
Q

Side effect of sotalol

A

prolongs QT and PR interval

21
Q

Limiting side effect of Quinidine

A

Prolongs QT interval

22
Q

MOA of class I A (eg. Procainamide), class IB (eg. Lidocaine), and class IC (eg. Flecainide) antiarrhythmics

A

Sodium channel blockers

23
Q

Antiarrhythmic that exhibits Class II and III properties

A

Sotalol

24
Q

Other side effects of Quinidine

A

Thrombocytopenic purpura, and CINCHONISM

25
Q

SE of Amiodarone

A

Thyroid dysfunction, photosensitivity, skin (blue smurf syndrome), corneal deposits, liver damage and pulmonary fibrosis

26
Q

Life threatening cardiac event that prolong QT leads to

A

Torsades de pointes