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Pharm One-Liners > Actions on Smooth Muscle > Flashcards

Actions on Smooth Muscle Flashcards

Drug Actions on Smooth Muscle

1
Q

Syndrome of hypersecretion of gastric acid and pepsin usually caused by gastrinoma; it is associated with severe peptic ulceration and diarrhea

A

Zollinger-Ellison Syndrome

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2
Q

Inhibitor of lipoxygenase

A

Zileuton

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3
Q

Inhibitor of leukotrienes (LTD4) receptors and used in asthma

A

Zafirlukast and montelukast

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4
Q

Reason ergot alkaloids are contraindicated in pregnancy

A

Uterine contractions

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5
Q

Major indication for H1 receptor antagonist

A

Use in IgE mediated allergic reaction (allergic rhinitis, urticaria)

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6
Q

5HT-1D/1B agonist used for migraine headaches

A

Sumatriptan, naratriptan, and rizatriptan

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7
Q

Triptan available in parenteral and nasal formulation

A

Sumatriptan

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8
Q

MOA and effect of nitric oxide

A

Stimulates cGMP which leads to vascular smooth muscle relaxation

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9
Q

Disease caused by excess ergot alkaloids

A

St. Anthony’s Fire

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10
Q

Distribution of histamine receptors H1, H2, and H3

A

Smooth muscle and mast cells; stomach, heart, and mast cells; nerve endings, CNS respectively

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11
Q

Most common side effect of 1st generation antihistamines

A

Sedation, anticholinergic

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12
Q

Long acting beta 2 agonist used in asthma

A

Salmeterol

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13
Q

Prostaglandins that cause abortions

A

Prostaglandin E1 (misoprostol), PGE2, and PGF2alpha

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14
Q

Enzyme which theophylline inhibits

A

Phosphodiesterase

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15
Q

Approved for use in severe pulmonary HTN

A

PGI2 (epoprostenol)

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16
Q

Used in pediatrics to maintain patency of ductus arteriosis

A

PGE1 (Alprostadil)

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17
Q

Prostaglandin used as 2nd line treatment of erectile dysfunction

A

PGE1 (Alprostadil)

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18
Q

Methylxanthine derivative used as a remedy for intermittent claudication

A

Pentoxifylline

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19
Q

Agents for reduction of postpartum bleeding

A

Oxytocin and ergonovine

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20
Q

Drug that causes contraction of the uterus

A

Oxytocin

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21
Q

5HT-3 antagonist used in chemotherapeutic induced emesis

A

Ondansetron, granisetron, dolasetron and palonosetron

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22
Q

Class of drugs that reversibly inhibit COX

23
Q

Drug used in ergot alkaloids overdose, ischemia and gangrene

A

Nitroprusside

24
Q

Receptors for serotonin (5HT-1) are located

A

Mostly in the brain, and they mediate synaptic inhibition via increased K+ conductance

25
Q

Ergot alkaloid used as an illicit drug

26
Q

Major SE of zileuton

A

Liver toxicity

27
Q

5HT2 antagonist mediate synaptic excitation in the CNS and smooth muscle contraction

A

Ketanserin, cyproheptadine, and ergot alkaloids (partial agonist of alpha and serotonin receptors)

28
Q

Muscarinic antagonist used in COPD

A

Ipratropium, tiotropium

29
Q

MOA of corticosteroids

A

Induce lipocortins to 1. inhibit phospholipase A2, 2. repress COX-2 gene and enzyme expression, 3. repress cytokines that activate COX-2

30
Q

SE of ergot alkaloids

A

Hallucinations resembling psychosis

31
Q

Generation of antihistamine that has the most CNS effects

A

First generation due to being more lipid-soluble

32
Q

2nd generation antihistamines

A

Fexofenadine, loratadine, and cetirizine

33
Q

5ht-3 antagonist that has been MOST associated with QRS and QTc prolongation and should not be used in patients with heart disease

A

Dolasetron

34
Q

Antihistamine that is indicated for allergies, motion sickness, and insomnia

A

Diphenhydramine

35
Q

1st generation antihistamine that is highly sedating

A

Diphendydramine

36
Q

H1 antagonist used in motion sickness

A

Dimenhydrinate and other 1st generation

37
Q

H1 blocker that is also a serotonin antagonist

A

Cyproheptadine

38
Q

Agents used in treatment of carcinoid tumor

A

Cyproheptadine

39
Q

Difference between COX 1 and COX 2

A

COX 1 is constitutive while COX 2 may be induced during inflammation, although COX 2 is constitutive in some tissues

40
Q

H2 blocker that causes the most interactions with other drugs

A

Cimetidine

41
Q

1st generation antihistamine that is least sedating

A

Chlorpheniramine

42
Q

Drug that selectively inhibits COX 2

43
Q

Drug causing depletion of substance P (vasodilator)

44
Q

Dopamine agonist used in hyperprolactinemia

A

Bromocriptine

45
Q

Peptide causing increased capillary permeability and edema

A

Bradykinin and histamine

46
Q

Mediator of tissue pain, edema, inactivated by ACE, and may be a contributing factor to the development of angioedema

A

Bradykinin

47
Q

MOA action of cromolyn

A

Blocks opening of Cl channels to prevent mast cell degranulation

48
Q

Antidote for severe CV toxicity of theophylline

A

Beta blockers

49
Q

A class of endogenous substances that include histamine, serotonin, prostaglandins, and vasoactive peptides that work in autocrine or paracrine manner

50
Q

Irreversible, nonselective COX inhibitor

A

Aspirin (or other salicylates)

51
Q

Primary endogenous substrate for Nitric Oxidase Synthase

52
Q

SE of long term (>5 days) corticosteroid therapy and remedy

A

Adrenal suppression and weaning slowly, respectively

53
Q

Clinical use for H2 blockers

A

Acid reflux disease, duodenal ulcer and peptic ulcer disease

Pharm One-Liners (46 decks)

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