NSAIDS and DMARDS Flashcards
Q
A
MOA of gold salts
Alter activity of macrophages and suppress phagocytic activity of PMNs
Four main actions of NSAIDS
Anti-inflammatory, analgesia, antipyretic and antiplatelet activity
Acetaminophen only has what activity?
Antipyretic and analgesic activity
SE of penicillamine
Aplastic anemia and renal
Difference between aspirin and other NSAIDS
Aspirin irreversibly inhibits cyclooxygenase
Newer NSAIDs that selectively inhibit COX-2
Celecoxib
SE of gold salts
Dermatitis of the mouth aplastic anemia and agranulocytosis
COX 2 inhibitors may have reduced risk of
Gastric ulcers and GI Bleeding
SE of acetaminophen
Hepatotoxicity
Interferes with activity of T-lymphocytes
Hydroxychloroquine
Anti-malarial drug used in rheumatoid arthritis (RA)
Hydroxychloroquine
Agent used for closure of patent ductus arteriosus
Indomethacin
Proteins that prevent action of tumor necrosis factor alpha (TNF-alpha)
Infliximab and etanercept
MOA of NSAIDS
inhibit prostaglandin synthesis by inhibiting cyclo-oxygenase (cox)
MOA of Leflunomide (newer agent)
Inhibiting Dihydroorotate Dehydrogenase which leads to decreased pyrimidine synthesis
NSAID available orally, IM, IV, nasally, and ophthalmically
Ketoralac
NSAID that is used for acute condition, such as pre-op anesthesia and has limited duration (<5 days) of use due to nephrotoxicity
Ketoralac
Causes bone marrow suppression
Methotrexate
Antidote for acetaminophen toxicity
N-acetylcysteine
The reason why aspirin is contraindicated in children with viral infection
Potential for development of Reye’s syndrome
COX 2 inhibitors should be used cautiously in pts with
Pre-existing cardiac or renal disease
SE of hydroxychloroquine
Retinal destruction and dermatitis
DMARDs are slow acting drugs for
Rheumatic disease
Anti-rheumatic agent also used for ulcerative colitis
Sulfasalazine
SE of salicylates
Tinnitus, GI bleeding
