arrt review: safety (radiation biology) Flashcards
(81 cards)
damaging effect from stochastic
cancer
damaging effect from deterministic
skin erythema, decreased sperm count, epilation, etc.
stochastic events are (predictable/unpredictable)
unpredictable
with stochastic effects, ___________ increases with dose but not the ___________
probability, severity
with deterministic effects, ___________ increases as dose increases
severity
Diminished sperm count dose threshold
150 mGy
skin erythema dose threshold
2,000 mGy
epilation dose threshold
3,000 mGy
is direct action common?
no
is DNA more often damage by direct or indirect action?
indirect
initial radiation interaction with direct action
radiation acts on DNA directly
initial radiation interaction with indirect action
radiation acts on water to create OH- and H+ which leads to broken DNA molecules
what type of DNA strand break is most damaging? is it the most common?
double strand break, least common
what type of DNA strand break is the most common?
base pair lesion
DNA strand breaks from most to least common
Base pair lesion, single strand break, double strand break
When will you see short term effects of radiation?
few days or hours
What is the latency period of leukemia?
5-7 years
what are examples of short effects?
skin burns, hair loss, ARS
what are examples of late effects?
Only 2 types = Cancer (stochastic) and cataracts (deterministic)
are short term effects stochastic or deterministic?
deterministic only
are long term effects stochastic or deterministic?
both
is cancer stochastic or deterministic?
stochastic
are cataracts stochastic or deterministic?
deterministic
When will you see late term effects of radiation?
years