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Flashcards in ART Therapy (lecture) Deck (20):
1

What is the expected increase in CD4 counts of people on effective ART therapy?

2x baseline every 3 - 6 months

2

What 4 conditions may indicate deferral of ART?

Barriers to adherence
Co morbidities complicate ART
Elite Controllers
Long-term non-progressor

3

What are the thee strategies of ART polyRx?

2 x NRTI + PI
2 x NRTI + NNRTI
2 x NRTI + integrase inhibitor

4

Lamivudine, Abacavir, Tenofovir, and Emtricitabine are all examples of what class of drugs?

NRTI

5

Which NRTI has the highest incidence of hypersensitivity?

Abacavir (5%)

6

What NRTI is given as a prophylactic for vertical transmission?

Tenovir
Note: This is a nucleoTIDE (not side)

7

What is the most commonly prescribed NNRTI?

Efavirenz

8

What is an absolute contraindication of Efavirenz?

Pregnancy, it is teratogenic

9

What is the suffix common to all protease inhibitors?

-navir

10

What metabolic abnormalities are a common side effect of protease inhibitors?

Hyperlipidemia, Hyperglycemia

11

What protease inhibitor is synergistic with other PIs?

Ritonavir

12

What is the most common side effect of Indinavir?

Kidney stones (made of the drug itself)

13

What dietary restriction is indicated in Atazanavir use?

Milk may inhibit absorption

14

What is the first line protease inhibitor?

Darunavir

15

What is the MoA of Enfuvirtide?

Fusion inhibitor (enFUvirtide prevents inFUsion) by blocking gp41

16

What is the MoA of Maraviroc?

Inhibits binding of HIV to CCR5 (maraviROC blocks binding)

17

What is the common suffix of integrase inhibitors?

-gravir
Raltegravire, Dolutegravir

18

What are the ARTs, from least to most commonly used?

HaHa. Just kidding. This changes too much for it to be tested. If you want to know, look at the lecture.

19

What is the immediate treatment given to neonates from an HIV + mother?

Ziduvudine (AZT)

20

What class of drugs are notorious for lactic acidosis as a side effect?

NRTIs