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Flashcards in SLE (lecture) Deck (17):
1

What antibody is most sensitive for SLE?

ANA

2

What tow antibodies are most specific for SLE?

Anti-dsDNA and Smith

3

What antibody is specific for drug induced SLE?

Anti-histone

4

Anti SCL-70 ab is a/w _____ _____ _____.

Diffuse systemic sclerosis

5

What antibody is a/w CREST?

Anti-centromere

6

Ro and La antibodies are a/w with which diseases (2)?

SLE and Sjorgen

7

What antibodies associated with SLE are responsible for hyper coagulability?

Anti-phospholypid antibodies

8

What type of hypersensitivity is responsible for the malar rash seen in SLE?

Type II - IgG / complement reaction

9

Where is the skin layers are IgG deposited in SLE rashes?

Dermal - Epidermal junction

10

How does discoid SLE antibody testing differ from malar?

discoid usually is sDNA negative, but still ANA pos

11

What are the 11 criteria for SLE?

Discoid
Oral ulcers
Photosensitive
Arthritis
Malar rash
Immun markers (dsDNA, Anti-Sm)
Neuro involvement
Elevated ESR

Renal involvement
ANA +
Serositis
Hem involved (Hemolytic anemia, Thrombocytopenia)
DOPAMINE RASH

12

What is the staining pattern of immuno fluorescence with glomerular SLE?

Diffuse and granular: http://www.theisn.org/education/education-topics/glomerular-disease/item/392-april2009

13

What 4 drugs are a/w drug induced SLE?

Hydralazine, procainamide, isoniazid, D-Penicillamine

14

What drug class is used in the treatment of acute flair ups of SLE?

Corticosteroid

15

What drug class is used in treatment of skin and organ involvement of SLE?

Anti-malarials

16

What drug is used to treat renal involvement of SLE?

Cyclophosphamide

17

What are the three most common causes of death in SLE?

Renal failure, CAD, Infection