Flashcards in SLE (lecture) Deck (17):
What antibody is most sensitive for SLE?
What tow antibodies are most specific for SLE?
Anti-dsDNA and Smith
What antibody is specific for drug induced SLE?
Anti SCL-70 ab is a/w _____ _____ _____.
Diffuse systemic sclerosis
What antibody is a/w CREST?
Ro and La antibodies are a/w with which diseases (2)?
SLE and Sjorgen
What antibodies associated with SLE are responsible for hyper coagulability?
What type of hypersensitivity is responsible for the malar rash seen in SLE?
Type II - IgG / complement reaction
Where is the skin layers are IgG deposited in SLE rashes?
Dermal - Epidermal junction
How does discoid SLE antibody testing differ from malar?
discoid usually is sDNA negative, but still ANA pos
What are the 11 criteria for SLE?
Immun markers (dsDNA, Anti-Sm)
Hem involved (Hemolytic anemia, Thrombocytopenia)
What is the staining pattern of immuno fluorescence with glomerular SLE?
Diffuse and granular: http://www.theisn.org/education/education-topics/glomerular-disease/item/392-april2009
What 4 drugs are a/w drug induced SLE?
Hydralazine, procainamide, isoniazid, D-Penicillamine
What drug class is used in the treatment of acute flair ups of SLE?
What drug class is used in treatment of skin and organ involvement of SLE?
What drug is used to treat renal involvement of SLE?