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Flashcards in Transplant Intro (lecture) Deck (12):
1

What is the anti-CD52 antibody covered in class?

Alemtuzumab - CD52 is believed to be part of lymphocyte activation

2

What are the two anti-IL2 receptor antibodies covered in class?

Basiliximab
Dacliximab

3

What are the two clacineurins covered in class?

Cylcosporine
Tacrolimus

4

What is the MoA of Azathioprine and Mycophenolate mofetil?

Inhibit DNA synth and preferentially target immune system cells

5

What are the two TOR (target of rapamycin) inhibitors?

Sirolimus
Everolimus

6

What two drugs target T-cell costimulation?

Belatacept
Abatacept
think of the T in both of them

7

Do you treat chronic rejection?

NO

8

Do you treat acute rejection?

Yes

9

What is the key cytokine in rejection?

IL-2

10

What is the cause of pneumonia in immunosuppressed patients on board questions?

CMV

11

What is the key cross matching?

MHC

12

If in doubt, what should be the drug answered?

cyclosporine