Flashcards in Asthma Deck (21)
Is asthma an obstructive or restrictive disease?
What happens to the basement membrane in remodelling?
What happens to the submucosa in remodelling?
What happens to smooth muscle in remodelling?
Asthmatics usually have a productive cough with wheeze. True/False?
Cough is usually dry/non-productive
What is wheeze?
High pitched expiratory sound
List the British Thoracic Society drug guidelines for asthma treatment
2. Inhaled steroid
+ CysLT receptor antagonist
3. Oral steroid
What are the benefits of a spacer?
Avoids coordination problems
Reduces oropharyngeal/laryngeal effects
Reduces particle size and velocity
Increases deposition into lungs
CysLT antagonists (Montelukast) are more potent than inhaled steroids. True/False?
2nd line additive to inhaled steroid
Cetirizine and Loratidine are sedative antihistamines. True/False?
They are non-sedative
What do anti-IgE monoclonal antibody treatments (Omalizumab) do?
Prevent binding to IgE receptor and inhibit mediator release from basophils and mast cells
What would be PEFR in moderate asthma?
Less than 80% predicted
What would be PEFR in severe asthma?
Less than 50% predicted
What would be PEFR in life threatening asthma?
Less than 30% predicted
Outline management of acute severe asthma
Magnesium sulphate (IV)
What is obstructive sleep apnoea?
Airway closure/obstruction during sleep, resulting in cessation of breathing
What are some symptoms of obstructive sleep apnoea?
Obesity and COPD are not risk factors for OSA. True/False?
What is the criteria for diagnosing OSA?
If more than 10-15 apnoeas in any 1hr of sleep
List features of an acute-severe asthma attack
Unable to finish sentences
PEFR less than 50% predicted
RR more than 25 breaths/min