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Flashcards in Asthma Deck (21)
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1

Is asthma an obstructive or restrictive disease?

Obstructive

2

What happens to the basement membrane in remodelling?

It thickens

3

What happens to the submucosa in remodelling?

Collagen deposition

4

What happens to smooth muscle in remodelling?

Hypertrophy

5

Asthmatics usually have a productive cough with wheeze. True/False?

False
Cough is usually dry/non-productive

6

What is wheeze?

High pitched expiratory sound

7

List the British Thoracic Society drug guidelines for asthma treatment

1. SABA
2. Inhaled steroid
+ LABA/LAMA
+ CysLT receptor antagonist
+ Theophylline
3. Oral steroid

8

What are the benefits of a spacer?

Avoids coordination problems
Reduces oropharyngeal/laryngeal effects
Reduces swallowing
Reduces particle size and velocity
Increases deposition into lungs

9

CysLT antagonists (Montelukast) are more potent than inhaled steroids. True/False?

False
2nd line additive to inhaled steroid

10

Cetirizine and Loratidine are sedative antihistamines. True/False?

False
They are non-sedative

11

What do anti-IgE monoclonal antibody treatments (Omalizumab) do?

Prevent binding to IgE receptor and inhibit mediator release from basophils and mast cells

12

What would be PEFR in moderate asthma?

Less than 80% predicted

13

What would be PEFR in severe asthma?

Less than 50% predicted

14

What would be PEFR in life threatening asthma?

Less than 30% predicted

15

Outline management of acute severe asthma

Oxygen (40-60%)
Salbutamol (nebulised)
Hydrocortisone (IV)
Ipratropium (nebulised)
Theophylline (oral)
Magnesium sulphate (IV)
Anaesthetist!

16

What is obstructive sleep apnoea?

Airway closure/obstruction during sleep, resulting in cessation of breathing

17

What are some symptoms of obstructive sleep apnoea?

Loud snoring
Daytime sleepiness
Headache

18

Obesity and COPD are not risk factors for OSA. True/False?

False
They are

19

What is the criteria for diagnosing OSA?

If more than 10-15 apnoeas in any 1hr of sleep

20

List features of an acute-severe asthma attack

Unable to finish sentences
PEFR less than 50% predicted
Tachycardia
RR more than 25 breaths/min

21

List features of a life-threatening asthma attack

PEFR less than 30% predicted
Bradycardia, hypotension, silent chest
Exhaustion/confusion
Hypoxia, acidosis