Flashcards in Restrictive Lung Diseases Deck (22)
Which structure(s) are mainly damaged in interstitial lung disease?
Alveolar walls and lumen
Causes impaired gas exchange
CO2 and O2 exchange is impaired. True/False?
CO2 exchange is unimpaired as it is very soluble
How can consolidation of alveolar spaces arise?
BOOP (none of above)
What is sarcoidosis?
Non-caseating granulomatous disease (Type IV hypersensitivity) of unknown aetiology
Sarcoidosis is less common in smokers. True/False?
List some clinical signs of sarcoidosis
Bilateral hilar lymphadenopathy
Is treatment given for sarcoidosis?
Oral steroids and immunosuppressives ONLY IF vital organs are being affected/chronic
Symptoms of EAA occur rapidly. True/False?
Typically several hours after exposure
How is EAA treated?
Oral steroids if very breathless
What is the most common ILD?
Idiopathic pulmonary fibrosis
What is the proposed aetiology of idiopathic PF?
Imbalance in fibrotic repair, resulting in scarring of the lung
Name some drugs which can cause IPF
Amiodarone, bleomycin, methotrexate
List some clinical signs of IPF
Bilateral fine inspiratory crackles
What is pneumoconiosis?
ILD caused by inhalation of occupational dusts
Describe the early and late stages of ILD
Early: alveolitis (inflammatory infiltrates)
Lung tissue becomes fibrous in IPF. What is the physiological consequence of this?
Reduced compliance (not as elastic)
Fibrosis due to asbestos exposure
IPF is commoner in females. True/False?
Commoner in males
What is heard on auscultation in IPF?
Fine bilateral end-inspiratory crackles
What is extrinsic allergic alveolitis?
Inflammation in airways due inhalation of foreign antigens, usually from animals
Smokers have increased risk of EAA. True/False?