COPD Flashcards Preview

1MB Respiratory > COPD > Flashcards

Flashcards in COPD Deck (14)
Loading flashcards...
1

What 2 conditions is COPD comprised of?

Emphysema + Chronic bronchitis
(ain't nobody got time fo dat)

2

What is chronic bronchitis?

Chronic neutrophilic inflammation in the bronchi/bronchioles, causing mucus hypersecretion and bronchospasms

3

What is emphysema?

Alveolar collapse, leading to impaired gas exchange

4

COPD patients have a productive cough, progressive breathlessness and frequent infective exacerbations. True/False?

True

5

What is an epidemiological definition of chronic bronchitis?

Cough + sputum on most days for at least 3 months of 2 successive years

6

What is meant by centriacinar emphysema?

Emphysema affecting proximal respiratory bronchioles; alveolar ducts + sacs remain in tact

7

What is meant by panacinar emphysema?

Emphysema affecting terminal bronchioles; destruction of whole alveolus

8

Describe how cor pulmonale (pulmonary heart failure) arises due to emphysema

Decreased gas exchange leads to decreased PaO2, which causes pulmonary vasoconstriction, increasing pressure in pulmonary arteries and thus the right side of the heart

9

Emphysema is common in people who are deficient of which antiprotease?

a1-antitrypsin

10

How does tobacco smoke affect the lung?

Increases no. of neutrophils and macrophages
Inhibits a1-antitrypsin

11

What are the 4 main symptoms of COPD?

Productive cough
Wheeze
Breathlessness
Infective exacerbations

12

What is the average % bronchodilator response in COPD?

Less than 15%

13

Outline treatment for mild to severe COPD

SAMA (mild)
SAMA + LAMA + LABA (moderate)
+ ICS (severe frequent exacerbations)

14

Outline treatment for acute exacerbation of COPD

Ipratropium neb
Salbutamol neb
Oxygen (24%)
Antibiotics if purulent sputum
Prednisolone oral