Awfully Specific Exam 1 Questions

Question 1

True/False: Agonists possess affinity only

Answer 1

FALSE- Antagonists possess affinity only

Question 2

True/False: The 1st pass effect applies to drugs administered orally

Answer 2

TRUE

Question 3

True/False: The uncharged form of a weak base with a pKa=8.2 would be most abundant at a pH=1.6

Answer 3

FALSE- A weak base will dissociate in an acidic solution and the charged form will dominate

Question 4

True/False: The charged form of a weak acid with a pKa=4.3 would be most abundant at a pH=2.8

Answer 4

FALSE- A weak acid will not dissociate in an acidic solution and the uncharged form will dominate

Question 5

True/False: If drug A is more potent than drug B, then drug B is more efficacious than drug A

Answer 5

FALSE- potency is amount of drug req for intended effect, efficacy is ability to produce physiological alteration

Question 6

True/False: Pareneteral administration of a drug is the most effect route of administration

Answer 6

FALSE- Multifactorial considerations

Question 7

True/False: Pharmocodynamics deals with the effects of a drug on the body

Answer 7

TRUE

Question 8

The liver plays a major role in drug excretion

Answer 8

TRUE

Question 9

Drugs administered IV have 1000% bioavailability

Answer 9

TRUE

Question 10

True/False: Tachycardia can result from the administration of metoprolol because it has β1 affinity

Answer 10

FALSE- Reflex tachycardia is β1-mediated so metoprolol blocks the reflex

Question 11

True/False: Tachycardia can result from the administration of bethanecol because it is a direct-acting muscarinic agonist

Answer 11

FALSE- no one cares

Question 12

True/False: Tachycardia can result from the administration of neostigmine because it is a muscarinic antagonist

Answer 12

FALSE- Neostigmine is a muscarinic agonist

Question 13

True/False: Tachycardia can result from the administration of phenylephrine because it increases SVR

Answer 13

FALSE- idk why

Question 14

True/False: A patient is administered a drug that stimulates nicotinic neuronal receptors. The drug will stimulate E secretion from the adrenal medulla

Answer 14

TRUE

Question 15

True/False: A patient is administered a drug that stimulates nicotinic neuronal receptors. The drug will cause diarrhea by directly stimulating β2 receptors

Answer 15

FALSE

Question 16

True/False: A patient is administered a drug that stimulates nicotinic neuronal receptors. The drug will decrease SVR by directly stimulating α1 receptors

Answer 16

FALSE- α1 receptors are not nicotinic receptors

Question 17

True/False: A patient is administered a drug that stimulates nicotinic neuronal receptors. The drug will cause spastic skeletal muscle paralysis

Answer 17

FALSE- nicotinic(muscle) stimulation will cause twitching

Question 18

True/False: Epinephrine is a positive chronotrope

Answer 18

TRUE

Question 19

True/False: Epinephrine decreases digestive system activity due to its β2 effect

Answer 19

TRUE

Question 20

True/False: Epinephrine is a positive inotrope

Answer 20

TRUE

Question 21

True/False: Epinephrine is a vasoconstrictor due to its α1 effect

Answer 21

TRUE

Question 22

True/False: Epinephrine is a vasodilator due to its β2 effect

Answer 22

TRUE

Question 23

True/False: Epinephrine is a bronchodilator due to its β2 effect

Answer 23

TRUE

Question 24

True/False: Atropine relaxes skeletal muscle because it is a cholinergic receptor antagonist

Answer 24

FALSE- ?

Question 25

True/False: Atropine is a positive chronotrope because it is an antimuscarinic drug

Answer 25

TRUE

Question 26

True/False: Atropine decreases bronchial mucous secretion by blocking Nn receptors

Answer 26

FALSE- ?

Question 27

True/False: Atropine is a bronchodilator

Answer 27

TRUE

Question 28

True/False: Labetalol causes reflex tachycardia

Answer 28

FALSE-Reflex tachycardia is β1-mediated so labetalol blocks the reflex

Question 29

True/False: Labetalol is a vasodilator

Answer 29

TRUE

Question 30

True/False: Labetalol can cause orthostatic hypotension by blocking adrenergic receptors

Answer 30

TRUE

Question 31

True/False: Labetalol lowers BP by reducing CO

Answer 31

TRUE

Question 32

True/False: Metoprolol lowers BP by reducing SVR

Answer 32

FALSE-

Question 33

True/False: Metoprolol directly reduces CO

Answer 33

TRUE

Question 34

True/False: Metoprolol targets the same receptors as dobutamine

Answer 34

TRUE

Question 35

True/False: Metoprolol causes reflex bradycardia

Answer 35

FALSE-Reflex tachycardia is β1-mediated so metoprolol blocks the reflex

Question 36

True/False: Phenylephrine causes reflex bradycardia because it reduces BP

Answer 36

FALSE-Phenylephrine stimulates α1 receptors- vasoconstriction would cause reflex tachycardia

Question 37

True/False: Phenylephrine targets a receptor targeted by NE

Answer 37

TRUE

Question 38

True/False: Phenylephrine directly increases myocardial contractility

Answer 38

FALSE-Phenylephrine stimulates α1 receptors causing vasoconstriction

Question 39

True/False: Phenylephrine is an effective decongestant

Answer 39

TRUE