B4 Infection and Immunity Flashcards Preview

Phase I Medicine > B4 Infection and Immunity > Flashcards

Flashcards in B4 Infection and Immunity Deck (19):
1

What is the consequence of a patient getting the wrong blood type during a transfusion?

Acute haemolytic reaction

2

What is an acute haemolytic reaction?

Circulating antibodies bind to RBCs and cause agglutination

3

What antibodies are responsible for targeting non-present ABO antigens?

IgM (Naturally occuring)

4

Which white blood cells are phagocytic?

Neutrophils
Eosinophils
Basophils
Monocytes

5

What percentage of white blood cells do neutrophils occupy?

70%

6

What is the lifespan of neutrophils?

5.4 days

7

At the site of inflammation, what is the lifespan of neutrophils?

1-2 days

8

Other than phagocytosis, how else do neutrophils kill pathogens?

Releasing granules containing toxic components

9

What are the main signs of inflammation?

Heat
Redness
Swelling
Pain

10

What is the term used to describe a matured neutrophil?

Segmented

11

What is responsible for connecting the lobules in a neutrophil?

Chromatin

12

How can neutrophilic bands be identified?

The nuclei are horseshoe or drumstick shaped

13

What are neutrophilic bands?

Immature neutrophils - a step away from becoming mature

14

What is the term used to describe a cell that has a kidney shaped nucleus but is not capable of division?

Neutrophilic metamyelocyte

15

What is a neutrophilic myelocyte?

A cell arising from progranulocytes
Contains differentiated granules and a nucleus with compact chromatin

16

What is another name for a progranulocyte?

Promyelocyte

17

What is a progranulocyte?

The first product of myeloblast differentiation

18

What are the properties of promyelocytes?

Large cells
Rounded nuclei
Basophilic cytoplasm with azurophilic granules

19

How much of marrow cells do promyelocytes represent?

4%