Infectious Diseases (Clinical) Flashcards

(34 cards)

1
Q

What is the most common syndrome in sub-saharan Africa?

A

Systemic febrile illness

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2
Q

What is the most common syndrome in south central Asia?

A

Acute diarrhoea

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3
Q

What is the most common syndrome in South America and the Caribbean

A

Dermatological disorder

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4
Q

Where is Malaria most prevalent?

A

Sub-Saharan Africa

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5
Q

Where is Dengue fever most prevalent?

A

South East Asia, Caribbean

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6
Q

Where is S. typhi/ parathyphi most prevalent?

A

South Central Asia

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7
Q

Where are Rickettsial diseases most prevalent?

A

Sub-Saharan Africa

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8
Q

Which infections are associated with short incubation periods (<10 days)?

A
COVID
Malaria (Falciparum)
Enteric bacteria
Pneumonia 
Dengue fever (+ other arbovirals)
Rickettsia
Viral haemorrhage fever
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9
Q

Which infections are associated with medium incubation periods (11-21 days)?

A
COVID
Malaria (Falciparum)
Leptospirosis
Lyme disease
Rickettsia
Strongyloides
Typhoid
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10
Q

Which infections are associated with long incubation periods (>21 days)?

A
Malaria (other species)
Amoebic liver abscess
Viral hepatitis
HIV
TB
Schistosomiasis
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11
Q

Give examples of malaria species that present after 21 days after going through their reproductive cycle in the liver

A

Vivax & ovale

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12
Q

What infectious disease differentials would you consider with jaundice?

A

Hepatitis, enteric fever, malaria

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13
Q

What infectious disease differentials would you consider with skin changes?

A

Schistosomiasis, arbovirus, rickettsial diseases

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14
Q

What infectious disease differentials would you consider with retinal/ conjunctival changes?

A

Haemorrhages (e.g. viral haemorrhage fever)

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15
Q

What infectious disease differentials would you consider with hepatosplenomegaly?

A

Malaria, dengue, enteric fever

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16
Q

What infectious disease differentials would you consider with eschars (ulcers with blackened centres)?

A

Rickettsial disease

17
Q

What infectious disease differentials would you consider with neurological sx?

A

Malaria, meninigitis, syphillis, TB

18
Q

What investigations would you add onto the standard ones in presentation of undifferentiated fever?

A

Blood gas
EBV/ CMV/ HIV serology
Malaria film x3
Swabs

19
Q

What infectious disease investigations would you consider with eosinophilia?

A

Stool x3 for ova, cysts + parasites
Terminal urine x3 for schistosome ova
Strongyloides, schistosome (filarial) serology

20
Q

What infectious disease investigations would you consider with diarrhoea?

A

Stool MCS (enteric pathogen panel)
Stool culture for ova, cysts and parasites
C diff screen

21
Q

What does high neutrophil count with no localising features suggest?

A

Septicaemia, leptospirosis

22
Q

What does high neutrophil count with localising features suggest?

A

Bacillary dysentery, tonsillitis

23
Q

Where neutrophils are normal or low, what may this suggest?

A

Malaria
Viral: dengue/ VHF/ acute HIV
Enteric fever
Rickettsia

24
Q

What does low platelet count suggest?

A
Malaria
Enteric fever
Dengue
Sepsis
HIV seroconversion
Other viral infections
25
True or false? Where platelet count is normal, malaria/ dengue fever are top differentials.
False
26
What is the management of uncomplicated falciparum malaria?
Artemisinin-based combination therapy (e.g. artesunate-mefloquine)
27
What is the management of dengue fever?
Supportive fluids, blood products
28
What is the management of enteric fever?
Ceftriaxone + supportive care | Adjust based on response and sensitivities
29
What is the management of legionella?
Erythromycin/ clarythromycin
30
What is the common triad of blood derangement in legionella?
Lymphopenia, hyponatraemia, deranged LFTs
31
What are characteristic signs of enteric fever?
Relative bradycardia, rose spots (on trunk of 30-40% of patients)
32
What is the first line management of early Lyme disease?
Doxycycline
33
What is the first line management of early Lyme disease in pregnancy?
Amoxicillin
34
What is the management of disseminated Lyme disease?
Ceftriaxone