Flashcards in Basal Ganglia Deck (15)
List the main components of the basal ganglia.
Striatum - Caudate ad Putamen
Globus Pallidus - External and Internal
Sub Thalamic Nucleus
Substantia Nigra - Pars Compacta Pars Reticulata
The direct pathway of the Basal Ganglia is intrinsic in what?
The initiation of movement
The first step in the direct pathway is what?
The cerebral cortex releases glutamate into the striatum..
An activated striatum does what?
Inhibits the Globus Pallidus Interna and Substantia Nigra Pars Reticula.
What is the function of an uninhibited Globus Pallidus Internal and substantia nigra pars reticula?
Release GABA into the thalamus suppressing movement.
As a result of GABA being released into the Globus Pallidus Interna and Substantia Nigra Pars Reticula what happens.
The two components are inhibited so less GABA is released in to the thalamus so it is activated.
An uninhibited thalamus does what?
Release Excitatory Glutamate to initiate movement.
What is the function of the Substantia Nigra Pars Compacta.
Modulates the indirect system - antagonist to the direct.
Draw the Direct Basal Ganglia Pathway
What does the SN Pars Compacta release into the striatum.
The release of dopamine from where into the striatum does what?
SN Pars Compacta
Increases the release of GABA.
Release of GABA into the where results in no inhibition of the Subthalamic Nuclei
GABA released from Striatum means that the Globus Pallidus Externa is inhibited so can't release inhibitory GABA into the Subthalamic nuclei.
As a result of the activation of the striatum by dopamine release what happens directly between the cerebral cortex and the sub thalamic nuclei?
Cerebral Cortex excites the Subthalamic nuclei which excite the GABA neurones in the Globus Pallidus Interna and the Substantia Nigra Reticula.
Activation of the GABA neurones in the Substantia NIgra Reticula and the Globus Pallidus Interna does what?
Inhibition of the thalamus