BB LRGPHOR Ch14 - Rabbit Viral Diseases Flashcards Preview

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Flashcards in BB LRGPHOR Ch14 - Rabbit Viral Diseases Deck (56):
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2. Myxoma virus in rabbits results in a severe, systemic disease in which species: a. Lepus tinidus b. Sylvilagus braziliensis c. Oryctolagus cuniculus d. Sylvilagus floridanus

c

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3. Which of the following contains only intracytoplasmic inclusions? a. Myxoma virus b. Rabbit Hemorrhagic Disease Virus c. Rabbit Oral Papillomavirus d. Herpesvirus cuniculi e. Rabbit Kidney Vacuolating Virus

a. Myxoma virus

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4. Which virus closely resembles Shope fibromatosis in Sylvilagus species, but causes a rapid, fatal infection in Oryctalagus species?

Myxoma virus

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5. What is a diagnostic distinction between Shope fibromatosis and papillomatosis in rabbits?

Presence of intranuclear inclusions

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6. Which of the following viruses of rabbits in the family Poxviridae is an Orthopoxvirus? a. Hare Fibroma Virus b. Rabbit (Shope) Fibroma Virus c. Myxoma Virus d. Rabbit Poxvirus

d. Rabbit Poxvirus

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7. Indicate whether the following viruses are DNA or RNA viruses: a. Rabbit Hemorrhagic Disease Virus b. Rabbit Fibroma Virus c. Leporid Herpesvirus 1 d. Rotavirus e. Lapine parvovirus f. Shope Papillomavirus

a. Rabbit Hemorrhagic Disease Virus - RNA b. Rabbit Fibroma Virus - DNA c. Leporid Herpesvirus 1 - DNA d. Rotavirus - RNA e. Lapine parvovirus - DNA f. Shope Papillomavirus - DNA

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8. Which of the following viruses is anthropozoonotic in humans and rabbits? a. Poxvirus b. Herpesvirus c. Papillomavirus d. Calicivirus

b

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9. To what genus does Cottontail Rabbit Papillomavirus belong? a. Papillomavirus b. Polyomavirus c. Kappapapillomavirus d. Betapapillomavirus

c

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10. True or False: Rabbit Oral Papillomavirus is immunologically identical to Cottontail Rabbit Papilomovirus.

FALSE

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11. Which of the following in nonpathogenic for all rabbit species? a. Rabbit Kidney Vacuolating Virus b. European Brown Hare Syndrome Virus c. Leporid parvovirus 4 d. Rabbit Hemorrhagic Disease Virus

a

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13. Which of the following is not typically a cause of diarrhea in young rabbits? a. Rabbit Hemorrhagic Disease Virus b. Rotavirus c. Coronaviral enteritis d. Colibacillosis

a

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14. Which of the following is most effective at eliminating rotavirus? a. Chlorine b. Formalin c. 95% Ethanol d. Betapropriolactone

c

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15. Which of the following is not a pathologic lesion associated with rotavirus? a. Intestines markedly congested and distended b. Villous blunting c. Mucosal hemorrhages d. Proliferative ileitis

d

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16. True or False: It is possible to rederive rabbits free of rotaviral infection through early weaning.

True

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17. Which of the following types of viruses may be a useful model for virus-induced cardiomyopathy? a. Coronavirus b. Calicivirus c. Parvovirus d. Bunyavirus

a

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18. The “etiologic agents of necrotic hepatitis of leporids” are classified as what type of viruses? a. Calicivirus b. Coronavirus c. Flavivirus d. Herpesvirus

a

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19. What is the most consistent finding in Rabbit Hemorrhagic Disease Virus?

Pale liver with periportal necrosis

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20. Which of the following viruses does not result in clinical disease in rabbits? a. European Brown Hare Syndrome Virus b. Rabbit Calicivirus c. Michigan Rabbit Calicivirus d. Rabbit Hemorrhagic Disease Virus

Rabbit Calicivirus

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21. Which of the following rat viruses do rabbits develop antibodies to? a. Sendai virus b. Rat Respiratory virus c. Sialodacryoadenitis Virus d. PVM

a

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22. Which of the following species is not involved in perpetuation of the flavivirus, Powassan virus? a. Peromyscus leucopus b. Lepus americanus c. Marmota monax d. Octodon degus

d

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Causative agent of myxomatosis

Myxoma virus

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Characteristics of myxoma virus

Family Poxviridae, genus Leporipoxvirus Enveloped double stranded DNA virus

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Clinical signs of myxomatosis

Oryctolagus - mucinous skin lesions and tumors, edema around mouth, nose, anus, genitals progressive conjunctivitis

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Epizootiology of myxoma virus

Oryctolagus particularly susceptible flea and mosquito vectors, direct contact Sylvilagus and Lepus spp. naturally susceptible

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Pathogenesis of myxomatosis

immunomodulatory proteins inhibit apoptosis, leukocyte chemotaxis, leukocyte activation

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Pathology of myxomatosis

myxomas - undifferentiated stellate mesenchymal cells embedded in mucinous matrix with capillaries and inflammatory cells

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Diagnosis of myxomatosis

PCR, ELISA, culture virus from tissue

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Differential diagnosis of myxomatosis

In Sylvilagus, lesions indistinguishable from rabbit fibroma virus - fibroma. Inoculate Oryctolagus with material to determine if it is myxoma virus (fatal) or fibroma virus (fibroma)

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Characteristics of Shope fibroma virus

Family Poxviridae, genus Leporipoxvirus similar to myxoma virus Enveloped, double stranded DNA virus

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Epizootiology of Shope fibroma virus

endemic in wild rabbits - causes fibromas skin tumors in domestic rabbits arthropod vectors spontaneously regress

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Clinical signs of Shope fibroma virus

flat, subcutaneous, easily movable tumors on legs and face

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Characteristics of rabbit pox virus

Family Poxviridae, genus Orthopoxvirus

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Clinical signs of rabbit pox virus

fever nasal discharge eye lesions - blepharitis, conjunctivitis, keratitis widespread skin lesions - macules/papules rash enlarged lymph nodes, facial edema

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Pathology of rabbit pox virus

nodules on liver, gall bladder, spleen, lung, repro organs widespread necrosis Cytoplasmic inclusions are reare

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Characteristics of Shope papilloma virus

Family Papovaviridae, genus Kappapapilomavirus nonenveloped double stranded DNA virus

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Clinical signs of Shope papilloma virus

horny warts an the neck, shoulders abdomen

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Epizootiology of Shope papilloma virus

widespread geographic distribution SCC in Sylvilagus spp. arthropod vector

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Characteristics of rabbit rotavirus

Family Reoviridae, group A, serotype 3 Nonenveloped double stranded RNA virus

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Clinical signs of rabbit rotavirus

anorexia, dehydration, watery to mucoid diarrhea, death

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Epizootiology of rabbit rotavirus

weanlings most susceptible newborns resistant due to passive immunity

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Pathology of rabbit rotavirus

villous atrophy, loss of small intestinal epithelial cells' lymphocytic infiltrate

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Diagnosis of rabbit rotavirus

immunoassays

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Characteristics of rabbit coronavirus

Family Coronaviridae Enveloped single stranded RNA virus

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Causative agent of rabbit hemorrhagic disease

Rabbit hemorrhagic disease virus family Caliciviridae nonenveloped single stranded RNA

45

Clinical syndromes of rabbit hemorrhagic disease

1. acute - anorexia, depression, neuro and resp. signs, ocular hemorrhage, epistaxis 2.peracute - sudden death 3. subacute - mild clinical signs

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Epizootiology

first described in China 1984 now widespread in Europe, Asia, Africa, Australia, NZ fecal oral transmission suspected fomite and arthropod vectors

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Pathology of rabbit hemorrhagic disease virus

periportal hepatic necrosis DIC, thrombosis

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Diagnosis of rabbit hemorrhagic disease

electron microscopy of liver tissue ELiSA

49

Differential diagnosis of rabbit hemorrhagic disease

European brown hare virus (calicivirus)

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This clinical condition is caused by what kind of virus?

a. polyomavirus

b. calicivirus

c. rotavirus

d. papillomavirus

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b. calicivirus

Rabbit hemorrhagic fever

genus:  Lagovirus

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Taxonomy of causative agent of this histopathology

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Family Poxviridae

Genus Leporipoxvirus

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which genus of rabbit is most susceptible to this diseasse?

a. Lepis

b. Sylvilagus

c. Oryctolagus

d. Bunolagus

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c. Oryctolagus

53

What is the genus of agent that causes this clinical presentation:

a. Leporipoxvirus

b. Orthopoxvirus

c. Kappapapillomavirus-1

d. Kappapapillomavirus-2

 

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c. Kappapapillomavirus-1

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What is the mode of transmission of the agent that causes this histopathologic presentation?

a. horizontal (placental)

b. fecal-oral

c. exposure to spores in the environment

d. arthropod vector

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b. fecal-oral

Rabbit hemorrhagic fever virus

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Arrows pointing to intranuclear inclusion bodies associated with what agent?

a. Leporipoxvirus

b. Kappapapillomavirus-1

c. Orthopoxvirus

d. Kappapapillomavirus-2

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a. Leporipoxvirus (Shope Fibroma virus)

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Causative agent of this condition:

a. Leporipoxvirus

b.Orthopoxvirus

c. ppapapillomavirus

d. Psoroptes

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a. Leporipoxvirus