Behcet's Disease

Question 1

What is Behcet’s Disease?

Answer 1

A complex inflammatory multisystem disorder of recurrent oral and genital ulcer

Behcet’s Disease is characterized by inflammation affecting multiple systems in the body.

Question 2

What gene is Behcet’s Disease associated with?

Answer 2

HLA-B51

HLA-B51 is a genetic marker that has been linked to an increased risk of developing Behcet’s Disease.

Question 3

What are the main features of Behcet’s Disease?

Answer 3

Oral ulcers, genital ulcers, anterior uveitis, DVTs, thrombophlebitis, erythema nodosum

These features reflect the systemic nature of the disease and its inflammatory characteristics.

Question 4

What are some of the differentials of oral ulcers?

Answer 4

Behcet’s Disease, Simple apthous ulcers, IBD, Coeliacs, B12 / Folate / Iron deficiency, HSV, Hand foot and mouth and SSC

Various conditions can cause oral ulcers, making differential diagnosis important.

Question 5

What is the main investigation for Behcet’s Disease?

Answer 5

Pathergy test

The pathergy test assesses the skin’s reaction to a needle prick and is used as a diagnostic tool for Behcet’s Disease.

Question 6

What is the management for Behcet’s Disease?

Answer 6

Steroids

Steroids are commonly used to manage inflammation and symptoms in patients with Behcet’s Disease.