Systemic Sclerosis Flashcards
(10 cards)
What is systemic sclerosis?
An autoimmune, inflammatory fibrotic connective tissue disorder
Systemic sclerosis is characterized by the hardening and tightening of the skin and connective tissues.
What are the three main forms of systemic sclerosis?
- Limited Cutaneous Systemic Sclerosis
- Diffuse Cutaneous System Sclerosis
- Scleroderma
Scleroderma is often used interchangeably with systemic sclerosis.
What is Limited Cutaneous Systemic Sclerosis (LCSS)?
LCSS has features of CREST (Calcinosis, Reynaud’s, Esophageal dysmotility, Sclerodactyly, Telangiectasia)
CREST syndrome is a subset of systemic sclerosis.
Where does Limited Cutaneous Systemic Sclerosis primarily affect?
Face and distal limbs
This form typically involves the skin of the face and fingers.
What is the antibody associated with Limited Cutaneous Systemic Sclerosis?
Anti-centromere antibodies
These antibodies are often used as a marker for LCSS.
What is Diffuse Cutaneous Systemic Sclerosis (DCSS)?
Has features of CREST, plus internal involvement of organs i.e. CV problems, lung problems, renal problems
DCSS tends to progress more rapidly than LCSS.
Where does Diffuse Cutaneous Systemic Sclerosis primarily affect?
Trunk and proximal limbs
This form involves more extensive skin involvement compared to LCSS.
What is the antibody associated with Diffuse Cutaneous Systemic Sclerosis?
Scl-70 antibodies
These antibodies are indicative of diffuse systemic sclerosis.
How can systemic sclerosis be diagnosed?
Nailfold capillaroscopy
This diagnostic method examines capillaries under the nailfold to identify abnormalities associated with systemic sclerosis.
