Paget's disease of Bone

Question 2

What is Paget’s disease?

Answer 2

A disease characterised by disordered bone turnover, both increased osteoclast and osteoblast activity

Paget’s disease leads to abnormalities in the way bones remodel and regenerate.

Question 3

Which bones are commonly affected by Paget’s disease?

Answer 3

Long bones, the skull, spine and pelvis

These areas are prone to the changes associated with Paget’s disease due to their structural importance.

Question 4

What are the symptoms of Paget’s disease?

Answer 4

Bone pain, fractures, hearing loss

These symptoms can significantly affect the quality of life and may require medical intervention.

Question 5

What is the specific blood test result associated with Paget’s disease?

Answer 5

Solitary rise in ALP

Alkaline phosphatase (ALP) is an enzyme that is commonly elevated in conditions involving increased bone turnover.

Question 6

What are XR findings in Paget’s disease?

Answer 6

Sclerosis and lysis, skull thickening, cotton wool skull, V shaped defects on long bones

These findings help radiologists and clinicians identify Paget’s disease through imaging studies.

Question 7

What is the management for Paget’s disease?

Answer 7

Bisphosphonates

Bisphosphonates are medications that help to inhibit bone resorption and are commonly used in treatment.

Question 8

What are the complications of Paget’s disease?

Answer 8

Osteosarcoma, spinal stenosis

These complications can arise due to the abnormal bone remodeling process seen in Paget’s disease.