BIO220 Lecture 9 Flashcards Preview

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Flashcards in BIO220 Lecture 9 Deck (63)
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31

Pandemic flu

Global outbreak of a flu transmitted from host to host. No immunity.

32

Pandemic flus

1. 1918 Spanish flu
2. 1957 Asian flu
3. 1968 Hong Kong flu

33

Avian flu

H5N1 virus found in birds:
deadly to domestic fowl and humans. No secondary infections.
No immunity, no vaccines.

34

Antigenic drift

Accumulation of many small mutations

35

Antigenic shift

Reassortment of RNA segments from different strains = gene flow

36

The Spanish Flu was due to...

antigenic drift; an avian strain that was able to secondary infect

37

Most influenza A viruses are descendent of...

1918 H1N1

38

The H1N1 occurred in ___ waves, and ___ happened between waves.

3
Drift

39

Who was most affected by the 1918 H1N1?

Young, old, middle age
(W shaped graph)

40

Who is usually most affected by the flu?

Young and old people (U shaped graph)

41

1918 H1N1 also appeared in what species?

Pigs

42

What made up the 2009 H1N1 virus?

3 pig viruses, avian, human viruses
-> antigenic shift

43

the 2009 H1N1 hit in ___ waves

2

44

2009 H1N1 originated in...

Mexico

45

Avian flu first appeared in...

Hong Kong

46

Poliomyetlitis

Virus that causes poliomyelitis

47

How do we get polio?

through the mouth

48

Where does poliomyelitis replicate?

GI tract

49

How is polio transmitted?

In feces

50

Where does poliomyelitis affect?

GI tract, bloodstream, CNS

51

what happens if the CNS is affected by polio?

Partial paralysis, maybe death

52

IPV

Inactivated Polio Vaccine

53

What is IPV inactivated with?

Formaldehyde

54

How is IPV administered?

syringe

55

OPV

Oral Polio Vaccine

56

How was OPV made?

Selected for low virulence strains of polio in monkey kidneys. These live, non-virulent strains was used for vaccination.

57

What are 2 advantages of OPV?

1. No needles needed
2. Vaccinated individual can vaccinate others

58

VAPP

Vaccine Associated Paralytic Polio

59

What caused VAPP?

Back mutations of OPV

60

What is VAPP?

After successful vaccinations, there were still some polio outbreaks (not completely gone). These outbreaks were due to VAPP.