Flashcards in BIO220 Lecture 9 Deck (63)
Global outbreak of a flu transmitted from host to host. No immunity.
1. 1918 Spanish flu
2. 1957 Asian flu
3. 1968 Hong Kong flu
H5N1 virus found in birds:
deadly to domestic fowl and humans. No secondary infections.
No immunity, no vaccines.
Accumulation of many small mutations
Reassortment of RNA segments from different strains = gene flow
The Spanish Flu was due to...
antigenic drift; an avian strain that was able to secondary infect
Most influenza A viruses are descendent of...
The H1N1 occurred in ___ waves, and ___ happened between waves.
Who was most affected by the 1918 H1N1?
Young, old, middle age
(W shaped graph)
Who is usually most affected by the flu?
Young and old people (U shaped graph)
1918 H1N1 also appeared in what species?
What made up the 2009 H1N1 virus?
3 pig viruses, avian, human viruses
-> antigenic shift
the 2009 H1N1 hit in ___ waves
2009 H1N1 originated in...
Avian flu first appeared in...
Virus that causes poliomyelitis
How do we get polio?
through the mouth
Where does poliomyelitis replicate?
How is polio transmitted?
Where does poliomyelitis affect?
GI tract, bloodstream, CNS
what happens if the CNS is affected by polio?
Partial paralysis, maybe death
Inactivated Polio Vaccine
What is IPV inactivated with?
How is IPV administered?
Oral Polio Vaccine
How was OPV made?
Selected for low virulence strains of polio in monkey kidneys. These live, non-virulent strains was used for vaccination.
What are 2 advantages of OPV?
1. No needles needed
2. Vaccinated individual can vaccinate others
Vaccine Associated Paralytic Polio
What caused VAPP?
Back mutations of OPV