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Flashcards in Biochem module 4 Deck (134):
0

Lipoproteins transport lipids from the intestines as
A. Chylomicron
B. VLDL
C. LDL
D. HDL

A.

1

Lipoproteins transport lipids from the liver as
A. Chylomicron
B. VLDL
C. LDL
D. HDL

B

2

The protein moiety of a lipoprotein is known as

Apoprotein or apolipoprotein

4

Main site of TAG synthesis

SER

5

Constituent of the plasma lipid that is the least abundant
A. triacylglycerols
B. phospholipids
C. cholesterol
D. cholesteryl esters
E. free fatty acids

E

7

Reduced form of iron

Ferrous ion Fe2+

8

Which of the ff is the largest
A. Chylomicron
B. VLDL
C.LDL
D. HDL

A

9

essential for chylomicron and VLDL formation
A. Apo A
B. Apo B
C. Apo C
D. Apo D

B

11

Which of the ff is not seen in the peripheral / outer side of the lipoprotein
A. TAG
B. integral apoprotein
C. Cholesterol
D. Phospholipid
E. Peripheral apoprotein

A. Yun mga non polar nasa loob like cholesteryl ester, FFA

13

Also known as pre beta lipoprotein

VLDL
LDL- beta lipoprotein
HDL - alpha lipoprotein

14

Plasma  glycoprotein  that  binds  extracorpuscular  Hb  in  a  ght noncovalent  complex

Haptoglobin

15

predominant lipid in HDL

Phospholipid

16

Rate limiting step in cholesterol synthesis

HMG CoA to mevalonate.. Enzyme is HMG CoA reductase

17

Where do Chylomicron remnants go to

Endocytosed by Liver for degradation and recycling

18

Free fatty acids are bound to _______ in the plasma

Albumin

19

Co factor of lipoprotein lipase
A. Apo A-I
B. Apo B -100
C. Apo C-II
D. Apo E

C

20

Chemical rxn occurring in the rate limiting step of cholesterol synthesis

Reduction

23

Apolipoprotein associated with Chylomicron

ApoB 48

24

The ff stimulate lipolysis except
A. Epinephrine
B. Glucagon
C. Nicotinic acid
D. Caffeine
E. Steroids

C. Inhibitory un insulin, and PGE

25

Ceruloplasmin acts by catalyzing
A. Converting iron ion to its reduced form
B. converting iron ion to its oxidized form

B

26

Hich of the ff statement is FALSE
A. Chylomicron is the largest among the lipoprotein
B. the primary apoprotein of IDL is B 100
C. HDL carries cholesterol to the liver
D. VLDL is primarily comprised of cholesterol
E. None of the above

D. Mostly TAG

27

What receptor in the liver recognizes HDL
A. SRB 1 receptor
B. LDL receptor
C. ABCA1 receptor
D. All of the above

A

28

Which of the ff stimulate lipid storage
A. Epinephrine
B. Glucagon
C. Nicotinic acid
D. Caffeine
E. Steroids

C

29

Adipose Cannot utilize glycerol to synthesize TAG because it lacks what enzyme

Glycerol kinase

30

Insulin
A. Stimulates lipoprotein lipase
B. Inhibits lipoprotein lipase

B

32

Rate limiting enzyme in cholesterol synthesis
A. HMG coA synthase
B. HMG coA reductase
C. HMG coA carboxylase
D. HMG coA lyase

B

33

Which of the ff is false
A. Chylomicron is the largest among lipoprotein
B. Chylomicron has the highest percentage of lipid
C. Chylomicron is the densest of all lipoprotein
D. Chylomicron is produced. In the small intestine

C. Least dense xa

36

Hormone sensitive lipase is inhibited by
A. Insulin
B. Glucagon

A. Glucagon stimulates it

37

Oversupply of the cholesterol leads to The ff except
A. Dec cholesterol synthesis
B. Increase LDL receptor
C. More LDL in the blood stream
D. HMG CoA reductase is inhibited

B. Dapat decrease.

38

StArting material of heme

Succinyl coA and glycine

39

In coagulation cascade, the Gla- containing factors have a high binding affinity for what ion
A. Mg
B. Ca
C. Fe
D. Si

B

40

The association of tissue factor and factor VIIa is called

Tissue factor complex

41

Which enzyme converts HDL to cholesteryl ester
A. ACAT
B. LCAT
C. HMG coA reductase
D. Acetyl coA kinase

B. Yun ACAT. LDL to cholesteryl ester

44

Main storage area of TAG

Adipose

45

Major  contributors  to  osmotic  pressure  of  plasma

Albumin

47

Most active of the plasma lipids

Free fatty acid

48

Glucose is transported to the adipose by
A. Glut 1
B. Glut 2
C. Glut 3
D. Glut 4

D

49

Oxidized LDL are also called as

Foam cells. They cause the atherosclerotic plaque

51

They are the vehicles of transport of triacylglycerol from the liver to the extrahepatic tissues
A. Chylomicron
B. VLDL
C. LDL
D. HDL

B

52

Precursor of all steroids in the body

Cholesterol

54

the vehicle of uptake of cholesterol and cholesteryl ester into many tissues
A. Chylomicron
B. VLDL
C. LDL
D. HDL

C

55

What metal is in the porphyrin ring of chlorophyll
A. Calcium
B. Iron
C. Magnesium
D, oxygen

C

56

Factor V is classified as
(1) zymogens of serine-protease
(2) cofactors
(3) fibrinogen
(4)a transglutaminase
(5) regulatory and other proteins

2.

Serine protease - factors 2,7,9,10,11,12
Cofactor -factors 3, 5, 8
Fibrinogen- factor 1
Transglutaminase- factor 13
Regulatory -protein c, protein s, thrombomodulin

57

What is the major protein component of plasma

Albumin

58

Insulin does the ff except
a. Inc hormone sensitive lipase
B. Inc cholesterol synthesis
C. Inc lipogenesis
D. None of the above

A. dapat dec

59

Cofactor in the rate limiting step of cholesterol synthesis

2 NADPH

60

Which of the ff has the highest protein content
A. Chylomicron
B. VLDL
C. LDL
D. HDL

D

61

Which of the ff statement is false
A. Heme synthesis involves the porphyrin and iron
B. Heme degradation produces iron and bilirubin
C. Type III porphyrin is classified as assymmetric substitution
D. Examples of type I porphyrin are heme and protoporphyrin IX

D. Type III

62

In order for hemoglobin to transport oxygen, it must be transported
A. In its ferrous form
B. in its ferric form

A

63

Rate limiting enzyme in bile acid synthesis

7 hydroxylase

64

Enzymes in the heme synthesis that is inhibited by lead

ALA dehydratase and ferrochelatase

65

The most prevalent metaloporphyrin in humans

Heme

67

What compound activates glycine

Pyridoxal phosphate

68

Apoproteins function as the ff except
A. Enzyme cofactor
B. Enzyme inhibitor
C. Ligand
D. Structure for lipoprotein
E. None of the above

E.

69

What metal is in the porphyrin ring of hemoglobin
A. Calcium
B. Iron
C. Magnesium
D, oxygen

B

70

Plasma  MINUS  CLOTTING  PROTEINS

Serum

71

The ff are examples of Beta protein except
A. Complement protein
B. Lipoprotein
C. Transferrin
D. Haptoglobin
E. Plasminogen

D. Alpha 2 xa

72

Which of the ff exhibits a broad peak
A. Albumin
B. Alpha 1
C. alpha 2
D. Beta
E. Gamma

E. Consists of many proteins so broad un peak.. Exhibits polymorphism

73

Most plasma proteins are produced in the liver except
A. Albumin
B. gamma globulin
C. Haptoglobin
D. Transferrin

B. pati un von wileband factor

74

The ff are examples of glycoprotein except
A. Haptoglobin
B. transferrin
C. IgE
D. Albumin

D. It is a pure protein

75

The ff plasma proteins exhibits polynmorphism except
A. ABO
B. alpha  1  antrypsin
C. haptoglobin
D. transferrin
E. ceruloplasmin

A. It exhibits polymorphism but not a plasma protein

76

Basis of immunoglobulin class

Heavy chain region

77

Alpha 1 anti trypsin is important in what organs ( name 2)

Lung and liver

78

the source of all carbon atoms in cholesterol

Acetyl coA

79

During acute phase inflammation, most plasma protein increase except ( name 2)

Albumin and transferrin

80

A patient presented you a result of his urinalysis. You noted that proteins are seen in his urine. What is most likely the condition the patient has
A. Nephrotic syndrome
B. Protein losing enteropathy
C. Malnutrition
D. Fever

A.

If sa feces most likely protein losing enteropathy

81

A patient has G6PD deficiency. While studying for his biochemistry exam, hemolytic anemia precipated. What would happen in his haptoglobin level
A. Increase
B. decrease
C. Same

B

82

A patient has deficiency in converting HMB to uroporphyrinogen III. He has
A. Acute intermittent porphyria
B. Variegate porphyria
C. Porphyria cutanea tarda
D. Congenital erythropoetic porphyria

D

83

Methemoglobinemia is characterized by
A. Reduced iron in the hemoglobin
B. oxidized iron in the hemoglobin

B

84

What plasma protein is Essential  for  the  absorption  of  iron  from  digested  food  by  small  intestine

Ceruloplasmin

85

A patient shows you his CBC result. You noted that there is an increase in lymphocyte. What does the patient most likely have
A. Staphylococcus aureus
B. wuchereria bancrofti
C. Flavivirus
D. Cryptococcosis neoformans

C.

Bacterial yun a.. Neutrophilia
Parasite yun b.. Eosinophilia

86

located  at  the  tips  of  the  angen  binding  sites

Hyper variable region

88

how  much  PLASMA  comprises  TOTAL  BODY  weight

5%

89

True or false. HMG coA synthesized in the cytosol is used for ketone body synthesis

False. For cholesterol synthesis.

HMG coA sa mitochondria un pang ketone bodies

90

predominant lipid in LDL

Cholesterol

91

Glucose transporter in RBC
A. Glut 1
B. glut 2
C. Glut 3
D. Glut 4

A

92

In iron deficiency anemia
A. Serum iron is low, there is increased ferric iron
B. serum iron is high, there is increased oxidized iron seen
C. serum iron is low! there is increased reduced iron seen
D. Serum iron is low, there is low ferrous iron

A

94

Main stimulus for erythropoietin

Hypoxia

95

Which of the ff statement is true
A. Topotent:  capable  of  producing  all  the  cells  in  an  organism
b. Pluripotent:  able  to  differenate  into  1 cell type  
C. Multipotent:  produce  cells in any of the germ layer  
d. Unipotent:  produce  only  cells of closely related family

A

97

rate-controlling enzyme in porphyrin biosynthesis

ALA synthase

98

The ff decreases cholesterol synthesis except
A. Dec in LDL
B. Low fat diet
C. Fasting
D. Dec in SREBP
E. Phosphorylation of HMG coA

D. Dapat increase

99

Protein involved in the formation of lipid droplets in adipocytes

Perilipin. Inhibits lipolysis

101

True or false. RBC contains both ICF and ECF

True

102

Constituent of the plasma lipid that is the most abundant
A. triacylglycerols
B. phospholipids
C. cholesterol
D. cholesteryl esters
E. free fatty acids

D

105

Receptor defective in familial hypercholesterolemia

LDL (B-100, E) receptor

106

The ff happens when cholesterol is esterified except
A. Becomes hydrophobic
B. Becomes hydrophilic
C. Becomes non polar
D. Becomes lipophilic

B

112

HMG coA is reduced to mevalonate in what organelle

Smooth ER

116

Which of the ff pairs is incorrectly paired
A. Uroporphyrin- acetate and propionate
B. coproporphyrin- methyl and proprionate
C. Protoporphyrin IX- vinyl, ethyl, proprionate

C. Instead of ethyl dapat methyl

118

Constituent of the plasma lipid that is the most active metabolically
A. triacylglycerols
B. phospholipids
C. cholesterol
D. cholesteryl esters
E. free fatty acids

E

119

The 4 pyrrole ring is joined by
A. Disulfide bond
B. methenyl bridge
C. Glycosidic bond
D. Covalent bond

B

125

Complex of tissue factor and factor VIIa can also activate what factor in the intrinsic pathway

factor IX

130

ALA dehydratase is inhibited by what element
A. Zinc
B. Gold
C. Lead
D. Tungsten

C

131

The ff will result when there is an increase in cholesterol synthesis except
A. Dec ACAT synthesis
B. Dec HMG coA reductase synthesis
C. Dec LDL receptor synthesis
D. None of the above

A. Dapat inc

132

Which of the ff has the highest lipid content
A. Chylomicron
B. VLDL
C. LDL
D. HDL

A

146

predominant lipid in chylomicrons and VLDL

Triacylglycerol

184

Deficiency with ALA synthase would result to

Anemia

185

Heme regulates
A. ALAS 1
B. ALAS 2

A

186

Which of the ff has the least amount of lipid
A. Chylomicron
B. VLDL
C. LDL
D. HDL

D

187

This type of hyperbilirubinemia is non responsive to phenobarbital treatment
A. crigler Najjar syndrome type I
B. Crigler Najjar syndrome type II
C. Gilbert's syndrome
D. Dubin Johnson syndrome

A

188

If a patient has high bilirubin and no urobilinogen in the urine. The patient has
A. Obstructive jaundice
B. Hemolytic jaundice

A

189

Which of the ff statement is true
A. Only conjugated bilirubin can Be found in the urine
B. Only un conjugated bilirubin can found in the urine
C. both conjugated and unconjugated bilirubin can be found in urine
D. No bilirubin will be found in the urine

A

190

Which of the ff statement is true
A. Only conjugated bilirubin can cross BBB
B. Only un conjugated bilirubin can cross BBB
C. both conjugated and unconjugated bilirubin will cross BBB
D. No bilirubin will cross BBB

B

191

Which of the ff terms is not related with each other
A. Retention hyperbilirubinemia
B. Choluric hyperbilirubinemia
C. Kernicterus
D. Unconjugated bilirubin

B

194

Bilirubin conjugation occurs in
A. Cytosol
B. Mitochondria
C. Endoplasmic reticulum
D. Nucleus

C

195

Which of the ff statement is false
A. Chylomicron are the biggest amongst lipoprotein
B. Chylomicron transports TAG to the liver
C. IDL cannot be determined in lipid profile test
D. High levels of HDL is bad

D

196

A patient has deficiency in converting uroporphyrinogen III to coproporphyrinogen III. He has
A. Acute intermittent porphyria
B. Variegate porphyria
C. Porphyria cutanea tarda
D. Congenital erythropoetic porphyria

C

197

If a patient has no bilirubin and high urobilinogen in the urine. The patient has
A. Obstructive jaundice
B. Hemolytic jaundice

B

198

A patient has deficiency in converting protoporphyrinogen III to protoporphyrin III. He has
A. Acute intermittent porphyria
B. Variegate porphyria
C. Porphyria cutanea tarda
D. Congenital erythropoetic porphyria

B

199

weak clot is strengthened by a covalent linkage. This is the action of
A. Factor va
B. Factor IIa
C. Factor xiiia
D. Factor xa

C

200

Patients with factor v Leiden have the ff characteristics except
A. Prone to venous thrombosis
B. there is arginine in the position 506
C. There is glutamine in position 506
D. Resistant to activated protein c

B.

201

A patient has uroporphyrinogen I synthase deficiency. Which of the ff statements is correct
A. He will experience photosensitivity
B. He has congenital erythropoetic porphyria
C. There is accumulation of PBG in his urine
D. Prophylaxis with NSAIDs can prevent the attack

C

202

Lipids must be transported as lipoprotein because
A. Lipids are inactive without the protein moiety
B. Lipids are too big for transport
C. Lipids are insoluble in water
D. Lipids can initiate antibody response

C

203

Which of the ff is false
A. Overproduction of bilirubin results in retention hyperbilirubinemia
B. Regurgitation hyperbilirubinemia causes Choluric jaundice
C. There are a lot of conjugated bilirubin in retention hyperbilirubinemia
D. Unconjugated bilirubin can enter BBB causing kernicterus

C

204

Oversupply of cholesterol would lead to the ff except
A. Dec cholesterol synthesis
B. Dec LDL receptor synthesis
C. Dec ACAT activity
D. Dec. HMG coA reductase activity

C

205

primary serine protease inhibitor of human plasma

Alpha 1 anti trypsin

206

Precursor of all steroids in the body

Cholesterol

207

The ff substance will INHIBIT lipolysis except
A. Caffeine.
B. Inhibitors of protein synthesis
C. Free fatty acids
D. TAG
E. Glucagon

A

208

Which of the ff statement is false
A. VLDL delivers de novo TAG to peripheral tissue
B. VLDL has the highest level of cholesterol
C. Chylomicron delivers dietary TAG to peripheral tissue
D. Apo E functions as ligand receptor while Apo C II functions as cofactor

B. LDL has the highest cholesterol content

209

Which of the ff are Amphipathic
A. TAG
B. free fatty acids
C. Cholesteryl ester
D. Cholesterol

D. Other choices are hydrophobic

212

Phosphorylated hormone sensitive lipase
A. Stimulates lipolysis
B. Inhibit lipolysis

A

213

During primary hemostasis, platelet plug are formed. During secondary hemostasis coagulation cascade occurs.
A. First sentence true, second false
B. First false, second true
C. Both true
D. Both false

C

214

A patient has deficiency in converting coproporphyrinogen III to protoporphyrinogen III. He has
A. Acute intermittent porphyria
B. Variegate porphyria
C. Porphyria cutanea tarda
D. Congenital erythropoetic porphyria
E. Hereditary coproporphyria

E

215

A patient is suffering from deficiency in platelet adhesion. He has
A. Gertsmann syndrome
B. Bernard- Soulier disease
C. Willebrand syndrome
D, Glanzmann's thrombesthenia

B. If deficiency sa platelet aggregation, Glanzmann's

216

End product of tissue factor pathway

Fibrin

217

Gla-containing zymogens except
A. Factor II
B. factor III
C. Factor VII
D. Factor IX
E. Factor x.

B

218

End product of contact activation pathway

Fibrin

219

the stimulus for the contact phase of the contact activation pathway
A. Releasing of vwf
B. Exposure of collagen to vessel surface
C. Hypoxia
D. Low carb diet

B

221

Important cofactor in the prothrombinase complex
A. Factor III
B. Factor V
C. Factor VIII
D. Factor XIII

B

222

The ff factors are activated by thrombin except
A. Factor V
B. Factor VII
C. Factor IX

C

223

Tissue factor pathway inhibitor with factor x. Inactivates
A .factor III
B. Factor VII
C. Factor X
D. All of the above

B

224

What factors is inhibited by protein c and s

Factor VIIIa and Va

225

The ff compounds inhibit platelet aggregation except
A. ADP
B. nitric oxide
C. Prostacyclin
D. Thrombomodulin

A

226

Factors inhibited by antithrombin III

Factors IXa, xa, IXa, XIIa

227

Which of the ff does not refer to heparin
A. Binds to antithrombin III
B. Is antagonized by strong anionic peptides
C. Inhibits factor Xa
D. Requires aPTT as monitoring parameter

B. Dapat cationic