Biochem module 3 Flashcards
(158 cards)
Rate limiting enzyme of lipogenesis
Acetyl coA carboxylase
Substrate of fatty acid synthesis
Acetyl coA
How many carbon is there in Lauric acid
12 Mnemonic LaMPSA Lauric 12 Myristic 14 Palmitate 16 Stearic 18 Arachidic 20
Main source of NADPH
PPP
Where does lipogenesis occur
Cytosol
Increase in acyl CoA would lead to
A. Inc lipogenesis
B. dec lipogenesis
B. kc inhibited un acetyl CoA carboxylase, tricarboxylate transporter and PDH
Where can acetyl CoA be made
Mitochondria
water soluble equivalents of fatty acids
Ketone bodies
Where does lipolysis occur
Mitochondria
Product of Lipogenesis
Free palmitate
How many ATP is produced in PPP
None
True or false. Lipogenesis and lipolysis involves simple reversal of reactions
False
Fasting
A. Increases lipogenesis
B. decreases lipogenesis
B
List all enzymes used in fatty acid synthesis
Acetyl coA carboxylase and fatty acid synthase
Acyl coA dehydrogenase needs what co factor
FAD
Write the chemical equation for beta oxidation stearic acid
Substrate. Stearic acid + 8 FAD + 8 NAD + 8 H2OProduct. 9 acetyl coA+ 8 NADPH + 8 FADH 2
What toxin characterizes Jamaican vomiting sickness
Hypoglycin
Cardohydrate in cardiac tissue A. ribose B. lyxose C. Arabinose D. Neuraminic acid
B
Where does oxidation of fatty acids occur
Mitochondria
Enzyme that converts FA to its activated form
Acyl coA synthetase
Main organ for excreting acetone
Oxidation in the Lungs…
Acetoacetate and beta hydroxybutyrate - extra hepatic tissue
Transketolases require what cofactor
Thiamine
Main building block of fatty acid
Acetyl coA
Total energy yield of beta oxidation Lauric acid
5 NADPH = 12.5 5 FADH2 = 7.5 6 acetyl coA = 60 Minus investment 2 Net ATP = 78