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Flashcards in Biochemical measurements Deck (16):
1

What is the best substance to measure GFR?

Inulin

2

What is the best endogenous substance to measure GFR?

Creatinine

3

What is clearance?

The volume of plasma that is theoretically cleared of a substance per minute

4

What is a better measurment than serum creatinine?

Creatinine clearance

5

What information do you need to calculate an estimated GFR?

Serum creatinine
Age
Sex
Ethnicity

6

Is eGFR more reliable at lower of higher GFR?

Lower. Becomes less accurate above 60

7

If it is essential to get an accurate assessment of GFR what test is done?

Inulin clearance

8

What test is used now to calculate eGFR?

4 variable MDRD

9

What protein levels in the urine suggest significant glomerular damage?

Above 150mg/day

10

What tests are useful in measuring proteinuria?

24 hour collection
Protein/creatinine ratio

11

What does microalbuminuria mean?

Excretion of abnormally high quantities of albumin but not high enough to sppear on a dipstick

12

What patients get routinely tested for microalbuminuria?

Diabetic patients

13

What biochemical sign is the earliest marker of diabetic nephropathy?

Microalbuminuria

14

A patients Urine:Serum osmolality is 1:1. What does this mean?

Intrinsic renal damage (tubules not working)

15

In the urinary sodium high or low in intrinsic renal damage?

High

16

What should the urine :serum ratio in a healthy patient be?

More than 10:1