Flashcards in Clinical questions Deck (29):
Ab 8 year old girl present with leg swelling, pre orbital oedema and frothy urine
Minimal change disease
What is the initial treatment for minimal change disease?
What is the treatment for minimal change disease which is resistant to steroids?
A 26 year old male who is on treatment for rheumatoid arthritis shows ++ protein and +blood.
Membranous nephropathy due to penicllamine or gold
What is the treatment for membrabous nephropathy?
What kidney disease are you most likely to get if you suffer from HIV?
Focal segmental glomerulosclerosis
An obese man present with frothy urine, haemature and hypertension.
Focal segmental glomerulosclerois
How do you treat focal segmantal glomerulosclerosis?
A teenage boy presents with haematuria> he says he notices blood in his urine the last time he had a cold. On dipstick he has +blood and +protein.
Which kidney disease is henoch schonlein purpura associated with?
HHow do you treat IgA nephropathy?
Tight BP control with ACE
Which renal condition is most associated with red cell casts?
Rapidly progressive glomerulonephritis
What do you see on biopsy with rapidly progressive glomerulonephritis?
Crescents on biopsy
Give three ANCA +ve causes of RPGN?
Give three ANCA -ve causes of PRGN
How do you treat goodpastures disease?
In what kidney disease do you get deposition of protein fragments and eosonophillic depositis in the mesangium?
What is the diagnositic criteria for overt diabetic nephropathy?
Persistent albuminuria (300mg/24h on at least 2 occasions separated by 3 - 6 months.
Describe the pathogenesis of diabetic nephropathy?
1. Haemodynamic changes cause an increase in GFR.
2. Glomerular basement membrane thickening.
3. mesangial expansion
4. proteinuria due to break down of podocytes.
5.Glomerulosclerosis with nodules
In which renal disease would you expect to see kimmelstiel wilson lesions (glomerulosclerosis with nodules)
What is the treatment for diabetic nephropathy?
Anti hypertensives (ACE and ARB)
what is the blood pressure target for a patient with diabetes?
Under 130mmHg sysstolic
Small vessel vasculitis
Characterised by chronic rhinosinusitis, asthma, and prominent peripheral blood eosinophilia
Lung most commonly involved (asthma in > 95%)
2/3 have skin involvement (palpable purpura to subcutaneous nodules)
Nasal crusting, sinusitis, persistent rhinorrhea, otitis media, oral/nasal ulcers, bloody nasal discharge
WG-evidence of bony/cartilage destruction (saddle nose)
List the classes of renal disease seen in SLE
Class I: Minimal mesangial
Class II: Mesangial Proliferative
Class III: Focal Proliferative
Class IV: Diffuse Proliferative
Class V: Membranous
Class VI: Advanced sclerosing
How does SLE kidney disease commonyl present?
What do you aim for the blood pressure to be in patients with proliferative SLE?
What is the treatment for proliferative SLE?