Flashcards in *Biochemistry Deck (21):
What is accuracy?
How close the result is to the true value
What is precision?
How predictable your results are
What is a false positive?
A healthy person who's result is in the disease territory and which therefore acts as a false alarm
What is a false negative?
A diseases whose result sin the healthy territory and which is therefore falsely reassuring
What is sensitivity?
The percentage of those of who have the disease who are correctly identified by a positive test result
What is specificity?
The proportion of those who do not have the disease who are correctly identified by a negative test result
What is the positive predictive value?
The proportion of those who test positive who actually have the disease
What is the negative predictive value?
The proportion of those who test negative who do not have the disease
What happens to PPV and NPV as the prevalence of a disease falls?
They both fall
When is there not much value in carrying out an investigation in terms of prevalence? Why?
When the prevalence is very low or very high - the PPV isn't very different from the probability - most useful when the prevalence is approximately 50%
What is the most sensitive biochemistry marker for an MI?
What causes the release of enzymes into the blood during pancreatitis?
Acute and chronic pancreatitis causes the release of some of the pancreases digestive enzymes into the pancreas itself, where they digest pancreatic tissue, releasing amylase and lipase into the blood
What is a dynamic function test?
Where a particular endocrine "axis" is tested dynamically, either by suppressing it or stimulating it in some way
Is normal urine acidic or alkaline?
How is carbonic acid removed?
What neutralises H+?
What is formed when H+ and bicarbonate combine?
Carbonic acid (removed as CO2)
What is acidaemia?
What is alkalaemia?
What is acidosis?
Process tending to cause increased [H+]