Biol 445 Test 1 Flashcards Preview

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Flashcards in Biol 445 Test 1 Deck (8)
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1

let-23

EGFR homologue
Vul mutation (recessive loss of function)
Expressed in VPCs

2

lin-3

EGF homologue
Vul mutation (recessive loss of function)
Expressed in ACs

3

lin-15

Negative regulator of vulval induction
Muv mutation (recessive loss of function)
Regulates localization of let-23 receptor

4

let-60

Ras homologue
Muv mutation (dominant gain of function)

5

sem-5

GRB2 homologue
Positive regulator

6

lin-45

Raf homologue

7

Having an abnormal amount of chromosomes and abnormal translocations

Aneuploidy

8

5 properties of cancer cells

Immortalized
Do not form differentiated tissues
No contact inhibition
Invasive
Escape apoptosis