Biology of Blood Diseases Unit 2 Flashcards Preview

Spring 2013 > Biology of Blood Diseases Unit 2 > Flashcards

Flashcards in Biology of Blood Diseases Unit 2 Deck (14):
1

Acute inflammation compared to Chronic

-Immediate and rapid
-Innate immunity
-Neutrophils predominant
-Lasts hours-weeks
-Prominent vascular response

2

Chronic inflammation compared to Acute

-Persistent and slow
-Cell-mediated immunity
-Mononuclear cells (monocytes, lymphocytes, plasma cells) predominant
-Lasts weeks to years
-Less prominent vascular response

3

Cardinal signs of inflammation

-redness
-heat
-swelling
-pain

4

Band neutrophil

Latest stage of immature neutrophil, analogous to reticulocyte for RBC

5

Myeloblast

Progenitor of GM-CFU, can differentiate into neutrophil or macrophage

6

Sequence of events of neutrophil responding to pathogenic insult

1) Margination
2) Adhesion
3) Emigration to chemotactic stimulus
4) Phagocytosis and intracellular degradation ("oxidative burst")
5) Extracellular release of leukocyte products

7

Lifespan of circulating neutrophils

6-10 hours

8

Exudate

high protein content edema (specific gravity > 1.015)

9

Transudate

low protein content edema (specific gravity < 1.015)

10

Most important bacteria causing meningitis

-Haemophilus influenzae b
-Neisseria meningitidis

11

Vasoactive mediators

anaphylatoxins:
-C4a
-C3a
-C5a

12

Chemoattractant

-C5a

13

Osponin (and function)

-C3b
molecule that, when coated on a pathogen, enhances phagocytosis

14

Functions of complement

-promote IgG-mediated cell killing
-promote vascular permeability
-coat foreign bacteria to mark destruction
-generates chemotaxins and pokes holes in bacteria