Blood Diseases Test 3 Flashcards Preview

Spring 2013 > Blood Diseases Test 3 > Flashcards

Flashcards in Blood Diseases Test 3 Deck (23):
1

HIV: Common opportunistic infections

Mycobacterium TB
Pneumocystis pneumonia (PCP)
Mycobacterium avium complex (MAC)
Anemia of chronic disease
Kaposi's sarcoma
NHL
Invasive cervical cancer

2

HIV gene: gag

codes for p24 vertical capsid, p6 and p7 nucleocapsid proteins, and p17 matrix protein

3

HIV gene: pol

codes for viral enzymes: reverse transcriptase, protease cleaving gag and pol, and integrase

4

HIV gene: env

codes for gp160, the precursor to gp120 and gp41

5

HIV: methods of destruction of CD4 T cells

Virus buds from and kills cell (includes apoptosis)
Normal immune response
Free gp120 binds to healthy cell
Infected cell binds to healthy cell (syncytium)

6

Normal platelet levels

150-400 x 10^9 / L

7

Heparin sulfate (HS)

anti-coagulant
binds antithrombin

8

Thrombomodulin (TM)

anti-coagulant
binds thrombin to activate protein C

9

Tissue plasminogen activator (tPA)

anti-coagulant
activates plasminogen

10

Proostacyclin (PGI2)

anti-coagulant
blocks platelet activation

11

Nitric oxide (NO)

anti-coagulant
vasodilator

12

CD39

anti-coagulant
inhibits platelet aggregation

13

Tissue factor (TF)

coagulant

14

Plasminogen activator inhibitor-1 (PAI-1)

coagulant
inhibits tPA

15

P-selectin

coagulant
promotes cell adhesion

16

Contents of alpha granules (platelets)

Coagulation factors (fibrinogen, vWF, coagulation factors V and VIII)
Platelet-derived growth factor (PDGF)

17

Contents of dense granules (platelets)

ADP, ATP, and serotonin

18

Steps of platelet activation

Platelet adhesion and shape change
Granule release
Platelet aggregation

19

Vitamin K-dependent factors

II, VII, IX, and X

20

PT (what it measures/ what's wrong if it's wrong)

Measures combined extrinsic pathway and common pathways
If it's wrong, deficiency with fibrinogen, prothrombin, FV, FX, or FVII

21

APTT (what it measures/ what's wrong if it's wrong)

Intrinsic and common pathways
If it's wrong, deficiency with fibrinogen, prothrombin, FV, FX, FXII, FXI, FIX, or FVIII

22

TCT (what it measures/ what's wrong if it's wrong)

Measures common pathway only
If it's wrong, deficiency with fibrinogen

23

Bleeding time/ PFA (what it measures/ what's wrong if it's wrong)

Measures platelet function
If it's wrong, deficiency with platelets