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Flashcards in Biol 445 student presentations Deck (24):
1

TGF-beta receptor 1/ALK 5 (types of cancer/disease cell function tumor suppressor/oncogene?)

Pancreatic, gastric, and lung cancers

Induces epithelial to mesenchymal transition (EMT)

Tumor suppressor in early stages (anti-growth) and oncogene later

2

Notch1 (types of cancer/disease cell function tumor suppressor/oncogene?)

T-ALL

Cellular "switch" promoting differentiation

Oncogene

3

Smoothened (types of cancer/disease cell function tumor suppressor/oncogene?)

Basal cell carcinoma

Regulation of cell differentiation and organ formation during embryonic development

Oncogene

4

BRCA2 (types of cancer/disease cell function tumor suppressor/oncogene?)

Breast cancer

Homologous recombination protein that repairs DNA breaks; G2 checkpoint regulator

Tumor suppressor

5

WT1 (Wilms tumor 1) (types of cancer/disease cell function tumor suppressor/oncogene?)

Childhood renal cancer

Zinc-finger TF mediating epithelial to mesenchymal transition (EMT)

Tumor suppressor

6

PTEN (types of cancer/disease cell function tumor suppressor/oncogene?)

Cowden syndrome

lipid phosphatase that opposes PI3K, controls growth

Tumor suppressor

7

Bcl-2 (types of cancer/disease cell function tumor suppressor/oncogene?)

Lymphoma

Protein embedded in mitochondrial membrane that prevents apoptosis

Oncogene

8

NF1 (types of cancer/disease cell function tumor suppressor/oncogene?)

Neurofibromatosis

GAP for Ras

Tumor suppressor

9

FANCD2 (types of cancer/disease cell function tumor suppressor/oncogene?)

Fanconi's anemia; sometimes leads to AML Cross-link repair and S phase arrest protein in the nucleus DNA repair/tumor suppressor

10

MLH1 (types of cancer/disease cell function tumor suppressor/oncogene?)

Hereditary non-polyposis cancer; endometrial cancer Recruits mismatch repair proteins to site of mismatch DNA repair; mutations increase propensity to acquire other mutations (no fit in classical definitions of tumor suppressor/oncogene)

11

BMP receptor 1A (types of cancer/disease cell function tumor suppressor/oncogene?)

Juvenille polyposis/ colon cancer A RTK ser/thr kinase Tumor suppressor

12

BRCA1 (types of cancer/disease cell function tumor suppressor/oncogene?)

Breast cancer

Forms complexes to repair double-stranded DNA breaks

DNA repair/tumor suppressor

13

NF2/Merlin (types of cancer/disease cell function tumor suppressor/oncogene?)

Schwannomas/meningiomas

Membrane-organizing protein that links actin cytoskeleton to plasma membrane; intercepts mitogenic signals

Tumor suppressor

14

Telomerase (types of cancer/disease cell function tumor suppressor/oncogene?)

Many cancers Elongates telomeres; not found in normal cells but is found in most cancer cells Oncogene (?)

15

Myc (types of cancer/disease cell function tumor suppressor/oncogene?)

Lymphoma/osteosarcoma

A transcription factor leading to unregulated gene expression

Oncogene

16

VHL (types of cancer/disease cell function tumor suppressor/oncogene?)

ccRCC (clear cell renal cell carcinoma); Von Hippel Lindau syndrome

Recruits other proteins to form a ubiqulase complex

Tumor suppressor

 

17

Patched (types of cancer/disease cell function tumor suppressor/oncogene?)

Basal cell carcinoma Small molecule modulator; Hedgehog receptor Tumor suppressor

18

PDGFR beta (types of cancer/disease cell function tumor suppressor/oncogene?)

CMML RTK that phosphorylates cell proliferation pathways (like Ras) Oncogene

19

p57 (types of cancer/disease cell function tumor suppressor/oncogene?)

Beckwith Weidemann Syndrome

Kinase inhibitor; arrests cells in G1

Tumor suppressor

20

Bloom helicase (types of cancer/disease cell function tumor suppressor/oncogene?)

Bloom syndrome ATP-dependent helicase with broad spectrum of functions including telomere replication and DNA damage repair Tumor suppressor

21

c-kit (types of cancer/disease cell function tumor suppressor/oncogene?)

GIST

Receptor tyrosine kinase

Oncogene

22

LKB1/STK (types of cancer/disease cell function tumor suppressor/oncogene?)

Peutz-Jegher's syndrome; many other cancers ser/thr kinase that activates AMPK cascade (cellular energy homeostasis) Tumor suppressor

23

HOX A9 (types of cancer/disease cell function tumor suppressor/oncogene?)

AML

Transcription factor that prevents differentiation and promotes proliferation

Oncogene

24

TGF-beta receptor 2 (types of cancer/disease cell function tumor suppressor/oncogene?)

Gastric, colon, pancreatic cancer

ser/thr kinase, forms heterotrimeric complex with type 1 receptors and propogates signals that do a bunch of stuff

Starts as tumor suppressor; becomes tumor promoter